Epigenetics & Nuclear Signaling Antibodies 4
Anti-MCRS1 Antibody (CAB8061)
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- SKU:
- CAB8061
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | MCRS1 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8061 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 203-462 of human MCRS1 (NP_006328.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Jurkat, MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 203-462 of human MCRS1 (NP_006328.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IQSK ALFS KAEE QLLS KVGS TSQP TLET FQDL LHRH PDAF YLAR TAKA LQAH WQLM KQYY LLED QTVQ PLPK GDQV LNFS DAED LIDD SKLK DMRD EVLE HELM VADR RQKR EIRQ LEQE LHKW QVLV DSIT GMSS PDFD NQTL AVLR GRMV RYLM RSRE ITLG RATK DNQI DVDL SLEG PAWK ISRK QGVI KLKN NGDF FIAN EGRR PIYI DGRP VLCG SKWR LSNN SVVE IASL RFVF LINQ DLIA LIRA EAAK ITPQ |
| Gene ID: | 10445 |
| Uniprot: | Q96EZ8 |
| Cellular Location: | Nucleus, nucleolus |
| Calculated MW: | 31kDa/50kDa/51kDa/53kDa |
| Observed MW: | 55kDa |
| Synonyms: | MCRS1, ICP22BP, INO80Q, MCRS2, MSP58, P78 |
| Background: |
| UniProt Protein Function: | MCRS1: Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nucleolus; Nuclear receptor co-regulator; RNA-binding Chromosomal Location of Human Ortholog: 12q13.12 Cellular Component: nucleoplasm; cytoplasm; nucleolus; cell junction; histone acetyltransferase complex; actin cytoskeleton Molecular Function:protein binding; histone acetyltransferase activity (H4-K16 specific) Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein modification process; DNA repair; DNA recombination |
| UniProt Code: | Q96EZ8 |
| NCBI GenInfo Identifier: | 24638035 |
| NCBI Gene ID: | 10445 |
| NCBI Accession: | Q96EZ8.1 |
| UniProt Secondary Accession: | Q96EZ8,O14742, O75497, Q6VN53, Q7Z372, |
| UniProt Related Accession: | Q96EZ8 |
| Molecular Weight: | 31,134 Da |
| NCBI Full Name: | Microspherule protein 1 |
| NCBI Synonym Full Names: | microspherule protein 1 |
| NCBI Official Symbol: | MCRS1 |
| NCBI Official Synonym Symbols: | P78; MCRS2; MSP58; INO80Q; ICP22BP |
| NCBI Protein Information: | microspherule protein 1; INO80 complex subunit J; INO80 complex subunit Q; 58 kDa microspherule protein; cell cycle-regulated factor p78; cell cycle-regulated factor (78 kDa) |
| UniProt Protein Name: | Microspherule protein 1 |
| UniProt Synonym Protein Names: | 58 kDa microspherule protein; Cell cycle-regulated factor p78; INO80 complex subunit J; MCRS2 |
| Protein Family: | Microspherule protein |
| UniProt Gene Name: | MCRS1 |
| UniProt Entry Name: | MCRS1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MCRS1 antibody (CAB8061) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |
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