Cell Biology Antibodies 15

Anti-MCOLN2 Antibody (CAB18560)

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SKU:
CAB18560
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MCOLN2 Antibody
Antibody SKU:CAB18560
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human MCOLN2.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Rat
Positive Samples:THP-1, SKOV3
Immunogen:Recombinant protein of human MCOLN2.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:255231
Uniprot:Q8IZK6
Cellular Location:
Calculated MW:
Observed MW:75kDa
Anti-MCOLN2 Antibody (CAB18560)Western blot - MCOLN2 Rabbit pAb (CAB18560)
Synonyms:TRP-ML2, TRPML2, MCOLN2
Background:
UniProt Protein Function:Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca2+-permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells. In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840).
NCBI Summary:Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009]
UniProt Code:Q8IZK6
NCBI GenInfo Identifier:54792073
NCBI Gene ID:255231
NCBI Accession:NP_694991.2
UniProt Secondary Accession:Q8IZK6,Q2M3I6, Q5TAG5, Q8N9R3, A6NI99,
UniProt Related Accession:Q8IZK6
Molecular Weight:62,685 Da
NCBI Full Name:mucolipin-2 isoform 1
NCBI Synonym Full Names:mucolipin 2
NCBI Official Symbol:MCOLN2  
NCBI Official Synonym Symbols:TRPML2; TRP-ML2  
NCBI Protein Information:mucolipin-2
UniProt Protein Name:Mucolipin-2
UniProt Synonym Protein Names:Transient receptor potential channel mucolipin 2; TRPML2
Protein Family:Mucolipin
UniProt Gene Name:MCOLN2  
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