| UniProt Protein Function: | Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca2+-permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells. In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). |
| NCBI Summary: | Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009] |
| UniProt Code: | Q8IZK6 |
| NCBI GenInfo Identifier: | 54792073 |
| NCBI Gene ID: | 255231 |
| NCBI Accession: | NP_694991.2 |
| UniProt Secondary Accession: | Q8IZK6,Q2M3I6, Q5TAG5, Q8N9R3, A6NI99, |
| UniProt Related Accession: | Q8IZK6 |
| Molecular Weight: | 62,685 Da |
| NCBI Full Name: | mucolipin-2 isoform 1 |
| NCBI Synonym Full Names: | mucolipin 2 |
| NCBI Official Symbol: | MCOLN2 |
| NCBI Official Synonym Symbols: | TRPML2; TRP-ML2 |
| NCBI Protein Information: | mucolipin-2 |
| UniProt Protein Name: | Mucolipin-2 |
| UniProt Synonym Protein Names: | Transient receptor potential channel mucolipin 2; TRPML2 |
| Protein Family: | Mucolipin |
| UniProt Gene Name: | MCOLN2 |
