Cell Cycle Antibodies 2

Anti-MCM5 Antibody (CAB5008)

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SKU:
CAB5008
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CDC46
Synonyms:
P1-CDC46
Research Area:
Cell Cycle

Description

Product Name:MCM5 Rabbit mAb
Product Code:CAB5008
Size:20uL, 50uL, 100uL
Synonyms:CDC46, P1-CDC46
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human MCM5
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, MCF7, Mouse spleen, Rat testis
Immunogen:A synthesized peptide derived from human MCM5
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4174
Uniprot:P33992
Calculated MW:82kDa
Observed MW:82KDa
UniProt Protein Function:MCM5: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Interacts with MCMBP. Belongs to the MCM family.
UniProt Protein Details:

Protein type:Cell cycle regulation; EC 3.6.4.12

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: nucleoplasm; MCM complex; membrane; nucleus

Molecular Function:DNA helicase activity; protein binding; DNA binding; ATP binding

Biological Process: DNA replication initiation; DNA strand elongation during DNA replication; mitotic cell cycle; DNA replication; DNA duplex unwinding; G1/S transition of mitotic cell cycle

NCBI Summary:The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]
UniProt Code:P33992
NCBI GenInfo Identifier:19858646
NCBI Gene ID:4174
NCBI Accession:P33992.5
UniProt Secondary Accession:P33992,O60785, Q14578, Q9BTJ4, Q9BWL8,
UniProt Related Accession:P33992
Molecular Weight:82,286 Da
NCBI Full Name:DNA replication licensing factor MCM5
NCBI Synonym Full Names:minichromosome maintenance complex component 5
NCBI Official Symbol:MCM5  
NCBI Official Synonym Symbols:CDC46; P1-CDC46  
NCBI Protein Information:DNA replication licensing factor MCM5; CDC46 homolog; minichromosome maintenance deficient 5 (cell division cycle 46); MCM5 minichromosome maintenance deficient 5, cell division cycle 46
UniProt Protein Name:DNA replication licensing factor MCM5
UniProt Synonym Protein Names:CDC46 homolog; P1-CDC46
Protein Family:Minichromosome maintenance protein
UniProt Gene Name:MCM5  
UniProt Entry Name:MCM5_HUMAN
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