Cell Cycle Antibodies 2
Anti-MCM3 Antibody (CAB11475)
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- SKU:
- CAB11475
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-MCM3 Antibody |
| Antibody SKU: | CAB11475 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human MCM3 |
| Application: | WB IHC IF IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, K-562, C6, Mouse spleen |
| Immunogen: | A synthesized peptide derived from human MCM3 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4172 |
| Uniprot: | P25205 |
| Cellular Location: | Nucleus |
| Calculated MW: | 100kDa |
| Observed MW: | 100KDa |
 | Western blot - MCM3 Rabbit mAb (CAB11475) |
| Synonyms: | HCC5, P1-MCM3, P1.h, RLFB |
| Background: | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012] |
| UniProt Protein Function: | MCM3: a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for DNA replication and cell proliferation. |
| UniProt Protein Details: | Protein type:EC 3.6.4.12; DNA replication Chromosomal Location of Human Ortholog: 6p12 Cellular Component: nucleoplasm; centrosome; alpha DNA polymerase:primase complex; membrane; intracellular membrane-bound organelle; MCM complex; perinuclear region of cytoplasm; nucleus Molecular Function:DNA helicase activity; protein binding; DNA binding; ATP binding Biological Process: DNA replication initiation; mitotic cell cycle; DNA strand elongation during DNA replication; DNA replication; DNA duplex unwinding; G1/S transition of mitotic cell cycle |
| NCBI Summary: | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012] |
| UniProt Code: | P25205 |
| NCBI GenInfo Identifier: | 19857543 |
| NCBI Gene ID: | 4172 |
| NCBI Accession: | P25205.3 |
| UniProt Secondary Accession: | P25205,Q92660, Q9BTR3, Q9NUE7, B4DWW4, |
| UniProt Related Accession: | P25205 |
| Molecular Weight: | 808 |
| NCBI Full Name: | DNA replication licensing factor MCM3 |
| NCBI Synonym Full Names: | minichromosome maintenance complex component 3 |
| NCBI Official Symbol: | MCM3 |
| NCBI Official Synonym Symbols: | HCC5; P1.h; RLFB; P1-MCM3 |
| NCBI Protein Information: | DNA replication licensing factor MCM3; p102; RLF subunit beta; hRlf beta subunit; DNA replication factor MCM3; cervical cancer proto-oncogene 5; minichromosome maintenance deficient 3; replication licensing factor, beta subunit; MCM3 minichromosome mainte |
| UniProt Protein Name: | DNA replication licensing factor MCM3 |
| UniProt Synonym Protein Names: | DNA polymerase alpha holoenzyme-associated protein P1; P1-MCM3; RLF subunit beta; p102 |
| Protein Family: | DNA replication licensing factor |
| UniProt Gene Name: | MCM3 |
| UniProt Entry Name: | MCM3_HUMAN |
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