Cell Biology Antibodies 12

Anti-MCF2L Antibody (CAB9966)

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SKU:
CAB9966
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MCF2L Antibody
Antibody SKU:CAB9966
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 850-980 of human MCF2L (NP_079255.4).
Application:WB
Recommended Dilution:WB 1:1000 - 1:4000
Reactivity:Human, Mouse
Positive Samples:MCF7, Mouse heart, Mouse kidney, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 850-980 of human MCF2L (NP_079255.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YEKA PSYS YKQS LNMA AVGI TENV KGDA KKFE IWYN AREE VYIV QAPT PEIK AAWV NEIR KVLT SQLQ ACRE ASQH RALE QSQS LPLP APTS TSPS RGNS RNIK KLEE RKTD PLSL EGYV SSAP LTKP PEK
Gene ID:23263
Uniprot:O15068
Cellular Location:Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein
Calculated MW:102-128kDa
Observed MW:128kDa
Synonyms:MCF2L, ARHGEF14, DBS, OST
Background:This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:ARHGEF14: Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus. Isoform 5 activates CDC42. Belongs to the MCF2 family. 8 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:GEFs, Rac/Rho; GEFs; Oncoprotein

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: cytosol; extracellular space

Molecular Function:guanyl-nucleotide exchange factor activity; phosphoinositide binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: positive regulation of apoptosis; regulation of small GTPase mediated signal transduction

NCBI Summary:This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Code:O15068
NCBI GenInfo Identifier:148887400
NCBI Gene ID:23263
NCBI Accession:O15068.2
UniProt Secondary Accession:O15068,Q5JU56, Q5VXT1, Q6ZWD4, Q765G8, A2A2X1, A2A2X2 A2A3G6, A2A3G8, B4DHD6, B4DIL6, E9PDN8,
UniProt Related Accession:O15068
Molecular Weight:126,111 Da
NCBI Full Name:Guanine nucleotide exchange factor DBS
NCBI Synonym Full Names:MCF.2 cell line derived transforming sequence like
NCBI Official Symbol:MCF2L  
NCBI Official Synonym Symbols:DBS; OST; ARHGEF14  
NCBI Protein Information:guanine nucleotide exchange factor DBS
UniProt Protein Name:Guanine nucleotide exchange factor DBS
UniProt Synonym Protein Names:DBL's big sister; MCF2-transforming sequence-like protein
Protein Family:Guanine nucleotide exchange factor
UniProt Gene Name:MCF2L  
UniProt Entry Name:MCF2L_HUMAN
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