| UniProt Protein Function: | KIF2C: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cancer Testis Antigen (CTA); Motor; Microtubule-binding Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: chromosome, pericentric region; cytoplasmic microtubule; cytosol; kinesin complex; kinetochore; membrane; microtubule cytoskeleton Molecular Function:ATPase activity; centromeric DNA binding; microtubule plus-end binding; protein binding Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; cell proliferation; establishment and/or maintenance of microtubule cytoskeleton polarity; microtubule depolymerization; microtubule-based movement; mitosis; mitotic metaphase plate congression; regulation of chromosome segregation; retrograde vesicle-mediated transport, Golgi to ER; sister chromatid cohesion |
| NCBI Summary: | This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q99661 |
| NCBI GenInfo Identifier: | 20141607 |
| NCBI Gene ID: | 11004 |
| NCBI Accession: | Q99661.2 |
| UniProt Secondary Accession: | Q99661,Q5JR88, Q6ICU1, Q96C18, Q96HB8, Q9BWV8, B3ITR9 |
| UniProt Related Accession: | Q99661 |
| Molecular Weight: | 75,561 Da |
| NCBI Full Name: | Kinesin-like protein KIF2C |
| NCBI Synonym Full Names: | kinesin family member 2C |
| NCBI Official Symbol: | KIF2C |
| NCBI Official Synonym Symbols: | MCAK; CT139; KNSL6 |
| NCBI Protein Information: | kinesin-like protein KIF2C |
| UniProt Protein Name: | Kinesin-like protein KIF2C |
| UniProt Synonym Protein Names: | Kinesin-like protein 6; Mitotic centromere-associated kinesin; MCAK |
| Protein Family: | Kinesin-like protein |
| UniProt Gene Name: | KIF2C |
| UniProt Entry Name: | KIF2C_HUMAN |
