Cell Cycle Antibodies 2
Anti-MCAK Antibody (CAB9140)
- SKU:
- CAB9140
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-MCAK Antibody |
| Antibody SKU: | CAB9140 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human MCAK |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | MCF7, PC-3, Jurkat |
| Immunogen: | A synthesized peptide derived from human MCAK |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 11004 |
| Uniprot: | Q99661 |
| Cellular Location: | |
| Calculated MW: | 81kDa |
| Observed MW: | 85KDa |
| Synonyms: | CT139, KNSL6, MCAK |
| Background: | This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Protein Function: | KIF2C: In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cancer Testis Antigen (CTA); Motor; Microtubule-binding Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: chromosome, pericentric region; cytoplasmic microtubule; cytosol; kinesin complex; kinetochore; membrane; microtubule cytoskeleton Molecular Function:ATPase activity; centromeric DNA binding; microtubule plus-end binding; protein binding Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; cell proliferation; establishment and/or maintenance of microtubule cytoskeleton polarity; microtubule depolymerization; microtubule-based movement; mitosis; mitotic metaphase plate congression; regulation of chromosome segregation; retrograde vesicle-mediated transport, Golgi to ER; sister chromatid cohesion |
| NCBI Summary: | This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q99661 |
| NCBI GenInfo Identifier: | 20141607 |
| NCBI Gene ID: | 11004 |
| NCBI Accession: | Q99661.2 |
| UniProt Secondary Accession: | Q99661,Q5JR88, Q6ICU1, Q96C18, Q96HB8, Q9BWV8, B3ITR9 |
| UniProt Related Accession: | Q99661 |
| Molecular Weight: | 75,561 Da |
| NCBI Full Name: | Kinesin-like protein KIF2C |
| NCBI Synonym Full Names: | kinesin family member 2C |
| NCBI Official Symbol: | KIF2C |
| NCBI Official Synonym Symbols: | MCAK; CT139; KNSL6 |
| NCBI Protein Information: | kinesin-like protein KIF2C |
| UniProt Protein Name: | Kinesin-like protein KIF2C |
| UniProt Synonym Protein Names: | Kinesin-like protein 6; Mitotic centromere-associated kinesin; MCAK |
| Protein Family: | Kinesin-like protein |
| UniProt Gene Name: | KIF2C |
| UniProt Entry Name: | KIF2C_HUMAN |
 | Western blot - MCAK Rabbit mAb (CAB9140) |
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