Neuroscience
Anti-MC4R Antibody (CAB10228)
- SKU:
- CAB10228
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Description
| Antibody Name: | Anti-MC4R Antibody |
| Antibody SKU: | CAB10228 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MC4R (NP_005903.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, PC-12, Mouse brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MC4R (NP_005903.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVNS THRG MHTS LHLW NRSS YRLH SNAS ESLG KGYS DGGC YEQL FVSP EVFV TLGV ISLL ENIL VIVA IAKN KNLH SPMY FFIC SLAV ADML VSVS NGSE |
| Gene ID: | 4160 |
| Uniprot: | P32245 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 36kDa |
| Observed MW: | 37kDa |
| Synonyms: | MC4R |
| Background: | The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. |
| UniProt Protein Function: | MC4R: receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. A G-protein coupled receptor that stimulates adenylate cyclase. Defects are a cause of autosomal dominant obesity |
| UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 18q21.32 Cellular Component: plasma membrane Molecular Function:melanocortin receptor activity; melanocyte stimulating hormone receptor activity; neuropeptide binding; protein binding; ubiquitin protein ligase binding Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; positive regulation of bone resorption; positive regulation of cAMP biosynthetic process Disease: Obesity |
| NCBI Summary: | The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010] |
| UniProt Code: | P32245 |
| NCBI GenInfo Identifier: | 60392672 |
| NCBI Gene ID: | 4160 |
| NCBI Accession: | P32245.2 |
| UniProt Secondary Accession: | P32245,Q16317, Q3MIJ6, B2RAC3, |
| UniProt Related Accession: | P32245 |
| Molecular Weight: | 37kDa |
| NCBI Full Name: | Melanocortin receptor 4 |
| NCBI Synonym Full Names: | melanocortin 4 receptor |
| NCBI Official Symbol: | MC4R |
| NCBI Protein Information: | melanocortin receptor 4 |
| UniProt Protein Name: | Melanocortin receptor 4 |
| Protein Family: | Melanocortin receptor |
| UniProt Gene Name: | MC4R |
 | Western blot analysis of extracts of various cell lines, using MC4R Antibody (CAB10228) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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