Cell Biology Antibodies 2

Anti-MC3R Antibody (CAB11609)

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SKU:
CAB11609
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MC3R Antibody
Antibody SKU:CAB11609
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human MC3R (NP_063941.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Mouse liver, Mouse kidney, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human MC3R (NP_063941.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNAS CCLP SVQP TLPN GSEH LQAP FFSN QSSS AFCE QVFI KPEV FLSL GIVS LLEN ILVI LAVV RNGN LHSP MYFF LCSL AVAD MLVS VSNA LETI MIAI VHSD YLTF EDQF IQHM DNIF
Gene ID:4159
Uniprot:P41968
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:36kDa
Observed MW:36kDa
Synonyms:MC3R, BMIQ9, MC3, MC3-R, OB20, OQTL
Background:This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans.
UniProt Protein Function:MC3R: Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 20q13.2-q13.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:neuropeptide binding; protein binding; melanocortin receptor activity; peptide hormone binding; melanocyte stimulating hormone receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; regulation of heart rate; homoiothermy; regulation of blood pressure; positive regulation of cAMP biosynthetic process; sodium ion homeostasis; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); circadian regulation of gene expression

Disease: Body Mass Index Quantitative Trait Locus 9; Mycobacterium Tuberculosis, Susceptibility To

NCBI Summary:This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008]
UniProt Code:P41968
NCBI GenInfo Identifier:395398606
NCBI Gene ID:4159
NCBI Accession:P41968.3
UniProt Related Accession:P41968
Molecular Weight:
NCBI Full Name:Melanocortin receptor 3
NCBI Synonym Full Names:melanocortin 3 receptor
NCBI Official Symbol:MC3R  
NCBI Official Synonym Symbols:MC3; OB20; OQTL; BMIQ9; MC3-R  
NCBI Protein Information:melanocortin receptor 3
UniProt Protein Name:Melanocortin receptor 3
Protein Family:Melanocortin receptor
UniProt Gene Name:MC3R  
UniProt Entry Name:MC3R_HUMAN
Anti-MC3R Antibody (CAB11609)Western blot analysis of extracts of various cell lines, using MC3R antibody (CAB11609) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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