Cell Biology Antibodies 8

Anti-MC2R Antibody (CAB3010)

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SKU:
CAB3010
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MC2R Antibody
Antibody SKU:CAB3010
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human MC2R
Application:WB IHC
Recommended Dilution:WB 1:1000 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:Raji, Mouse kidney
Immunogen:Recombinant protein of human MC2R
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4158
Uniprot:Q01718
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:33kDa
Observed MW:37kDa
Synonyms:MC2R, ACTHR
Background:MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene.
UniProt Protein Function:MC2R: Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase. Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1); also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18p11.2

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function:protein binding; melanocortin receptor activity; adrenocorticotropin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; positive regulation of cAMP biosynthetic process; placenta development

Disease: Glucocorticoid Deficiency 1

NCBI Summary:MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014]
UniProt Code:Q01718
NCBI GenInfo Identifier:399002
NCBI Gene ID:4158
NCBI Accession:Q01718.1
UniProt Secondary Accession:Q01718,Q3MI45, Q504X6, A8K016,
UniProt Related Accession:Q01718
Molecular Weight:297
NCBI Full Name:Adrenocorticotropic hormone receptor
NCBI Synonym Full Names:melanocortin 2 receptor (adrenocorticotropic hormone)
NCBI Official Symbol:MC2R  
NCBI Official Synonym Symbols:ACTHR  
NCBI Protein Information:adrenocorticotropic hormone receptor; MC2 receptor; ACTH receptor; corticotropin receptor; adrenocorticotropin receptor
UniProt Protein Name:Adrenocorticotropic hormone receptor
UniProt Synonym Protein Names:Adrenocorticotropin receptor; Melanocortin receptor 2; MC2-R
Protein Family:Adrenocorticotropic hormone receptor
UniProt Gene Name:MC2R  
UniProt Entry Name:ACTHR_HUMAN
Anti-MC2R Antibody (CAB3010)Western blot analysis of extracts of various cell lines, using MC2R antibody (CAB3010) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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