Immunology Antibodies 2
Anti-MBL2 Antibody (CAB5825)
- SKU:
- CAB5825
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-MBL2 Antibody |
| Antibody SKU: | CAB5825 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-248 of human MBL2 (NP_000233.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-248 of human MBL2 (NP_000233.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ETVT CEDA QKTC PAVI ACSS PGIN GFPG KDGR DGTK GEKG EPGQ GLRG LQGP PGKL GPPG NPGP SGSP GPKG QKGD PGKS PDGD SSLA ASER KALQ TEMA RIKK WLTF SLGK QVGN KFFL TNGE IMTF EKVK ALCV KFQA SVAT PRNA AENG AIQN LIKE EAFL GITD EKTE GQFV DLTG NRLT YTNW NEGE PNNA GSDE DCVL LLKN GQWN DVPC STSH LAVC EFPI |
| Gene ID: | 4153 |
| Uniprot: | P11226 |
| Cellular Location: | Secreted |
| Calculated MW: | 26kDa |
| Observed MW: | 24kDa |
| Synonyms: | MBL2, COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP-C, MBP1, MBPD |
| Background: | This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. |
| UniProt Protein Function: | MBL2: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 10q11.2 Cellular Component: extracellular space; cell surface; collagen; extracellular region Molecular Function:mannose binding; protein binding; calcium ion binding; calcium-dependent protein binding; receptor binding Biological Process: defense response to Gram-positive bacterium; killing by host of symbiont cells; positive regulation of phagocytosis; defense response to bacterium; acute-phase response; innate immune response; response to oxidative stress; opsonization; complement activation, lectin pathway; complement activation, classical pathway; negative regulation of viral reproduction; complement activation Disease: Mannose-binding Protein Deficiency |
| NCBI Summary: | This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P11226 |
| NCBI GenInfo Identifier: | 4557739 |
| NCBI Gene ID: | 4153 |
| NCBI Accession: | NP_000233.1 |
| UniProt Secondary Accession: | P11226,Q4VB12, Q4VB13, Q86SI4, Q96KE4, Q96TF7, Q96TF8 Q96TF9, |
| UniProt Related Accession: | P11226 |
| Molecular Weight: | 26,144 Da |
| NCBI Full Name: | mannose-binding protein C |
| NCBI Synonym Full Names: | mannose-binding lectin (protein C) 2, soluble |
| NCBI Official Symbol: | MBL2 |
| NCBI Official Synonym Symbols: | MBL; MBP; MBP1; MBPD; MBL2D; MBP-C; COLEC1; HSMBPC |
| NCBI Protein Information: | mannose-binding protein C; collectin-1; mannan-binding lectin; mannose-binding lectin 2, soluble (opsonic defect); mannose-binding lectin (protein C) 2, soluble (opsonic defect) |
| UniProt Protein Name: | Mannose-binding protein C |
| UniProt Synonym Protein Names: | Collectin-1; MBP1; Mannan-binding protein; Mannose-binding lectin |
| Protein Family: | Mannose-binding protein |
| UniProt Gene Name: | MBL2 |
| UniProt Entry Name: | MBL2_HUMAN |
 | Western blot analysis of extracts of Rat liver, using MBL2 antibody (CAB5825) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min. |
 | Immunohistochemistry of paraffin-embedded mouse stomach using MBL2 antibody (CAB5825) (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver damage using MBL2 antibody (CAB5825) (40x lens). |
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