Epigenetics & Nuclear Signaling Antibodies 1

Anti-MBD3L1 Antibody (CAB12081)

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SKU:
CAB12081
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-MBD3L1 Antibody
Antibody SKU:CAB12081
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-194 of human MBD3L1 (NP_660209.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat testis, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-194 of human MBD3L1 (NP_660209.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAKS SQRK QRDC VNQC KSKP GLST SIPL RMSS YTFK RPVT RITP HPGN EVRY HQWE ESLE KPQQ VCWQ RRLQ GLQA YSSA GELS STLD LANT LQKL VPSY TGGS LLED LASG LEHS CPMP HLAC SSDA VEII PAEG VGIS QLLC KQFL VTEE DIRK QEGK VKTV RERL AIAL IADG LANE AEKV RDQE GRPE KR
Gene ID:85509
Uniprot:Q8WWY6
Cellular Location:Nucleus
Calculated MW:21kDa
Observed MW:22kDa
Synonyms:MBD3L1, MBD3L
Background:This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein is localized to discrete areas in the nucleus, and expression appears to be restricted to round spermatids, suggesting that the protein plays a role in the postmeiotic stages of male germ cell development.
UniProt Protein Function:MBD3L1: Transcriptional repressor. Belongs to the MBD3L family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytoplasm; nucleoplasm; nucleus; plasma membrane

Molecular Function:methyl-CpG binding

Biological Process: methylation-dependent chromatin silencing; negative regulation of transcription from RNA polymerase II promoter

NCBI Summary:This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein is localized to discrete areas in the nucleus, and expression appears to be restricted to round spermatids, suggesting that the protein plays a role in the postmeiotic stages of male germ cell development. [provided by RefSeq, Jul 2008]
UniProt Code:Q8WWY6
NCBI GenInfo Identifier:296436435
NCBI Gene ID:85509
NCBI Accession:Q8WWY6.2
UniProt Secondary Accession:Q8WWY6,Q2M291, B5BUM6,
UniProt Related Accession:Q8WWY6
Molecular Weight:21,616 Da
NCBI Full Name:Methyl-CpG-binding domain protein 3-like 1
NCBI Synonym Full Names:methyl-CpG binding domain protein 3 like 1
NCBI Official Symbol:MBD3L1  
NCBI Official Synonym Symbols:MBD3L  
NCBI Protein Information:methyl-CpG-binding domain protein 3-like 1
UniProt Protein Name:Methyl-CpG-binding domain protein 3-like 1
Protein Family:Methyl-CpG-binding domain protein
UniProt Gene Name:MBD3L1  
UniProt Entry Name:MB3L1_HUMAN
Anti-MBD3L1 Antibody (CAB12081)Western blot analysis of extracts of various cell lines, using MBD3L1 antibody (CAB12081) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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