Epigenetics & Nuclear Signaling Antibodies 5
Anti-MBD2 Antibody (CAB11982)
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- SKU:
- CAB11982
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-MBD2 Antibody |
| Antibody SKU: | CAB11982 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human MBD2 (NP_003918.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | mouse heart |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human MBD2 (NP_003918.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IKTM ELPK GLQG VGPG SNDE TLLS AVAS ALHT SSAP ITGQ VSAA VEKN PAVW LNTS QPLC KAFI VTDE DIRK QEER VQQV RKKL EEAL MADI LSRA ADTE EMDI EMDS GDEA |
| Gene ID: | 8932 |
| Uniprot: | Q9UBB5 |
| Cellular Location: | Nucleus |
| Calculated MW: | 31kDa/43kDa |
| Observed MW: | 43kDa |
 | Western blot - MBD2 Rabbit pAb (CAB11982) |
| Synonyms: | MBD2, DMTase, NY-CO-41 |
| Background: | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | MBD2: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. May enhance the activation of some unmethylated cAMP-responsive promoters. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 18q21 Cellular Component: nucleoplasm; heterochromatin; protein complex; cytoplasm; nuclear chromatin; histone deacetylase complex; nucleus Molecular Function:mRNA binding; protein domain specific binding; protein binding; nucleosomal DNA binding; siRNA binding; methyl-CpG binding; satellite DNA binding Biological Process: cellular protein complex assembly; transcription, DNA-dependent; maternal behavior; negative regulation of gene expression, epigenetic; ATP-dependent chromatin remodeling; gene expression; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of Wnt receptor signaling pathway; regulation of gene expression, epigenetic; regulation of cell proliferation |
| NCBI Summary: | DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] |
| UniProt Code: | Q9UBB5 |
| NCBI GenInfo Identifier: | 50401198 |
| NCBI Gene ID: | 8932 |
| NCBI Accession: | Q9UBB5.1 |
| UniProt Related Accession: | Q9UBB5 |
| Molecular Weight: | 56kDa; 62kDa |
| NCBI Full Name: | Methyl-CpG-binding domain protein 2 |
| NCBI Synonym Full Names: | methyl-CpG binding domain protein 2 |
| NCBI Official Symbol: | MBD2 |
| NCBI Official Synonym Symbols: | DMTase; NY-CO-41 |
| NCBI Protein Information: | methyl-CpG-binding domain protein 2 |
| UniProt Protein Name: | Methyl-CpG-binding domain protein 2 |
| UniProt Synonym Protein Names: | Demethylase; DMTase; Methyl-CpG-binding protein MBD2 |
| Protein Family: | Methyl-CpG-binding domain protein |
| UniProt Gene Name: | MBD2 |
| UniProt Entry Name: | MBD2_HUMAN |
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