Metabolism Antibodies 2
Anti-MAT1A Antibody (CAB2630)
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- SKU:
- CAB2630
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-MAT1A Antibody |
| Antibody SKU: | CAB2630 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-395 of human MAT1A (NP_000420.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-395 of human MAT1A (NP_000420.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNGP VDGL CDHS LSEG VFMF TSES VGEG HPDK ICDQ ISDA VLDA HLKQ DPNA KVAC ETVC KTGM VLLC GEIT SMAM VDYQ RVVR DTIK HIGY DDSA KGFD FKTC NVLV ALEQ QSPD IAQC VHLD RNEE DVGA GDQG LMFG YATD ETEE CMPL TIIL AHKL NARM ADLR RSGL LPWL RPDS KTQV TVQY MQDN GAVI PVRI HTIV ISVQ HNED ITLE EMRR ALKE QVIR AVVP AKYL DEDT VYHL QPSG RFVI GGPQ GDAG VTGR KIIV DTYG GWGA HGGG AFSG KDYT KVDR SAAY AARW VAKS LVKA GLCR RVLV QVSY AIGV AEPL SISI FTYG TSQK TERE LLDV VHKN FDLR PGVI VRDL DLKK PIYQ KTAC YGHF GRSE FPWE VPRK LVF |
| Gene ID: | 4143 |
| Uniprot: | Q00266 |
| Cellular Location: | |
| Calculated MW: | 43kDa |
| Observed MW: | 44kDa |
| Synonyms: | MAT1A, MAT, MATA1, SAMS, SAMS1 |
| Background: | This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. |
| UniProt Protein Function: | MAT1A: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. Defects in MAT1A are the cause of methionine adenosyltransferase deficiency (MATD); also called MAT I/III deficiency. MATD is an inborn error of metabolism resulting in isolated hypermethioninemia. Most patients have no clinical abnormalities, although some neurologic symptoms may be present in rare cases with severe loss of methionine adenosyltransferase activity. Belongs to the AdoMet synthase family. |
| UniProt Protein Details: | Protein type:EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Amino Acid Metabolism - cysteine and methionine; Transferase Chromosomal Location of Human Ortholog: 10q22 Cellular Component: cytosol Molecular Function:methionine adenosyltransferase activity Biological Process: amino acid metabolic process; methylation; selenium metabolic process; sulfur amino acid metabolic process Disease: Methionine Adenosyltransferase Deficiency |
| NCBI Summary: | This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q00266 |
| NCBI GenInfo Identifier: | 417297 |
| NCBI Gene ID: | 4143 |
| NCBI Accession: | Q00266.2 |
| UniProt Secondary Accession: | Q00266,Q5QP09, D3DWD5, |
| UniProt Related Accession: | Q00266 |
| Molecular Weight: | 43,648 Da |
| NCBI Full Name: | S-adenosylmethionine synthase isoform type-1 |
| NCBI Synonym Full Names: | methionine adenosyltransferase 1A |
| NCBI Official Symbol: | MAT1A |
| NCBI Official Synonym Symbols: | MAT; SAMS; MATA1; SAMS1 |
| NCBI Protein Information: | S-adenosylmethionine synthase isoform type-1 |
| UniProt Protein Name: | S-adenosylmethionine synthase isoform type-1 |
| UniProt Synonym Protein Names: | Methionine adenosyltransferase 1; MAT 1; Methionine adenosyltransferase I/III; MAT-I/III |
| Protein Family: | S-adenosylmethionine synthase |
| UniProt Gene Name: | MAT1A |
| UniProt Entry Name: | METK1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MAT1A antibody (CAB2630) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
 | Immunohistochemistry of paraffin-embedded human liver damage using MAT1A antibody (CAB2630) at dilution of 1:100 (40x lens). |
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