Anti-Mast Cell Tryptase (TPSB2) Antibody (CAB19801)

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SKU:
CAB19801
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
TPS2
Synonyms:
tryptaseB
Synonyms:
tryptaseC
Research Area:
Immunology

Description

Product Name:Mast Cell Tryptase (TPSB2) Rabbit mAb
Product Code:CAB19801
Size:20uL, 50uL, 100uL
Synonyms:TPS2, tryptaseB, tryptaseC
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Mast Cell Tryptase (TPSB2) (TPSB2)
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse skin, Rat skin
Immunogen:A synthesized peptide derived from human Mast Cell Tryptase (TPSB2) (TPSB2)
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:64499
Uniprot:P20231
Calculated MW:30kDa
Observed MW:31KDa
UniProt Protein Function:TPSB2: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection. Belongs to the peptidase S1 family. Tryptase subfamily.
UniProt Protein Details:

Protein type:EC 3.4.21.59; Secreted; Secreted, signal peptide; Protease

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: extracellular region

Molecular Function:protein binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: proteolysis

NCBI Summary:Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
UniProt Code:P20231
NCBI GenInfo Identifier:13775595
NCBI Gene ID:7177
NCBI Accession:NP_003285.2
UniProt Secondary Accession:P20231,O95827, Q15664, Q9UQI6, Q9UQI7, D2E6S0, D2E6S2
UniProt Related Accession:Q15661
Molecular Weight:30,515 Da
NCBI Full Name:tryptase alpha/beta-1
NCBI Synonym Full Names:tryptase alpha/beta 1
NCBI Official Symbol:TPSAB1  
NCBI Official Synonym Symbols:TPS1; TPS2; TPSB1  
NCBI Protein Information:tryptase alpha/beta-1; tryptase I; tryptase-1; tryptase-I; tryptase-III; tryptase beta 1; tryptase beta I; tryptase beta-1; tryptase alpha-1; tryptase alpha II; mast cell beta I tryptase; mast cell alpha II tryptase
UniProt Protein Name:Tryptase beta-2
UniProt Synonym Protein Names:Tryptase II
Protein Family:Tryptase
UniProt Gene Name:TPSB2  
UniProt Entry Name:TRYB2_HUMAN
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