Immunology Antibodies 2
Anti-MASP1 Antibody (CAB5693)
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- SKU:
- CAB5693
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-MASP1 Antibody |
| Antibody SKU: | CAB5693 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human MASP1 (NP_001870.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human MASP1 (NP_001870.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HTVE LNNM FGQI QSPG YPDS YPSD SEVT WNIT VPDG FRIK LYFM HFNL ESSY LCEY DYVK VETE DQVL ATFC GRET TDTE QTPG QEVV LSPG SFMS ITFR SDFS NEER FTGF DAHY MAVD VDEC KERE DEEL SCDH YCHN YIGG YYCS CRFG YILH TDNR TCRV ECSD NLFT QRTG VITS PDFP NPYP KSSE CLYT IELE EGFM VNLQ FEDI FDIE DHPE VPCP YDYI KIKV GPKV LGPF CGEK APEP ISTQ SHSV LILF HSDN SGEN RGWR LSYR AAGN E |
| Gene ID: | 5648 |
| Uniprot: | P48740 |
| Cellular Location: | Secreted |
| Calculated MW: | 43kDa/68kDa/79kDa/81kDa |
| Observed MW: | 60kDa |
| Synonyms: | MASP1, 3MC1, CRARF, CRARF1, MAP1, MASP, MASP3, MAp44, PRSS5, RaRF |
| Background: | This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | MASP1: Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Defects in MASP1 are the cause of 3MC syndrome type 1 (3MC1). 3MC1 is a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. Belongs to the peptidase S1 family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.21.-; Protease; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 3q27-q28 Cellular Component: extracellular space; extracellular region Molecular Function:peptidase activity; protein binding; protein homodimerization activity; serine-type endopeptidase activity; calcium ion binding; calcium-dependent protein binding Biological Process: receptor-mediated endocytosis; negative regulation of complement activation; innate immune response; proteolysis; complement activation, lectin pathway; complement activation Disease: 3mc Syndrome 1 |
| NCBI Summary: | This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010] |
| UniProt Code: | P48740 |
| NCBI GenInfo Identifier: | 218512135 |
| NCBI Gene ID: | 5648 |
| NCBI Accession: | P48740.3 |
| UniProt Secondary Accession: | P48740,O95570, Q68D21, Q8IUV8, Q96RS4, Q9UF09, A8K542 A8K6M1, B4E2L7, |
| UniProt Related Accession: | P48740 |
| Molecular Weight: | 699 |
| NCBI Full Name: | Mannan-binding lectin serine protease 1 |
| NCBI Synonym Full Names: | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) |
| NCBI Official Symbol: | MASP1 |
| NCBI Official Synonym Symbols: | 3MC1; MAP1; MASP; RaRF; CRARF; MASP3; MAp44; PRSS5; CRARF1 |
| NCBI Protein Information: | mannan-binding lectin serine protease 1; serine protease 5; complement factor MASP-3; Ra-reactive factor serine protease p100; mannose-binding protein-associated serine protease; mannose-binding lectin-associated serine protease 1; complement-activating component of Ra-reactive factor |
| UniProt Protein Name: | Mannan-binding lectin serine protease 1 |
| UniProt Synonym Protein Names: | Complement factor MASP-3; Complement-activating component of Ra-reactive factor; Mannose-binding lectin-associated serine protease 1; MASP-1; Mannose-binding protein-associated serine protease; Ra-reactive factor serine protease p100; RaRF; Serine protease 5Cleaved into the following 2 chains:Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain |
| Protein Family: | Mannan-binding lectin serine protease |
| UniProt Gene Name: | MASP1 |
| UniProt Entry Name: | MASP1_HUMAN |
 | Western blot analysis of extracts of HeLa cells, using MASP1 antibody (CAB5693) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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