Metabolism Antibodies 3
Anti-MARK1 Antibody (CAB8435)
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- SKU:
- CAB8435
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-MARK1 Antibody |
| Antibody SKU: | CAB8435 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 560-700 of human MARK1 (NP_061120.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, U-87MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 560-700 of human MARK1 (NP_061120.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HPIK VTLP TIKD GSEA YRPG TTQR VPAA SPSA HSIS TATP DRTR FPRG SSSR STFH GEQL RERR SVAY NGPP ASPS HETG AFAH ARRG TSTG IISK ITSK FVRR DPSE GEAS GRTD TSRS TSGE PKER DKEE GKDS KPRS L |
| Gene ID: | 4139 |
| Uniprot: | Q9P0L2 |
| Cellular Location: | Cell membrane, Cytoplasm, Peripheral membrane protein, cytoskeleton |
| Calculated MW: | 72kDa/84kDa/89kDa |
| Observed MW: | 95kDa |
| Synonyms: | MARK1, MARK, Par-1c, Par1c |
| Background: |
| UniProt Protein Function: | MARK1: a member of the CAMKL family of protein kinases. The MARK group of kinases is apparently involved in the control of cell polarity, microtubule stability and cancer. MARK1 forms a tight association with Tau in neurofibrillary tangles in Alzheimer disease tissue. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; EC 2.7.11.1; EC 2.7.11.26; CAMK group; CAMKL family; MARK subfamily Chromosomal Location of Human Ortholog: 1q41 Cellular Component: cytoplasm; cytoskeleton; microtubule cytoskeleton; plasma membrane Molecular Function:ATP binding; magnesium ion binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; protein serine/threonine kinase activity; tau-protein kinase activity Biological Process: cytoskeleton organization and biogenesis; neuron migration; protein amino acid phosphorylation; Wnt receptor signaling pathway |
| UniProt Code: | Q9P0L2 |
| NCBI GenInfo Identifier: | 124056494 |
| NCBI Gene ID: | 4139 |
| NCBI Accession: | Q9P0L2.2 |
| UniProt Secondary Accession: | Q9P0L2,Q2HIY1, Q5VTF9, Q5VTG0, Q96SW9, Q9P251, D3DTB0 D3DTB1, |
| UniProt Related Accession: | Q9P0L2 |
| Molecular Weight: | 84,911 Da |
| NCBI Full Name: | Serine/threonine-protein kinase MARK1 |
| NCBI Synonym Full Names: | microtubule affinity regulating kinase 1 |
| NCBI Official Symbol: | MARK1 |
| NCBI Official Synonym Symbols: | MARK; Par1c; Par-1c |
| NCBI Protein Information: | serine/threonine-protein kinase MARK1 |
| UniProt Protein Name: | Serine/threonine-protein kinase MARK1 |
| UniProt Synonym Protein Names: | MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | MARK1 |
| UniProt Entry Name: | MARK1_HUMAN |
 | Immunohistochemistry of paraffin-embedded mouse lung using MARK1 antibody (CAB8435) at dilution of 1:100 (40x lens). |
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