Immunology Antibodies 1

Anti-MARCO Antibody (CAB10048)

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SKU:
CAB10048
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-MARCO Antibody
Antibody SKU:CAB10048
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 421-520 of human MARCO (NP_006761.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, K-562, Mouse spleen, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 421-520 of human MARCO (NP_006761.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SVSV RIVG SSNR GRAE VYYS GTWG TICD DEWQ NSDA IVFC RMLG YSKG RALY KVGA GTGQ IWLD NVQC RGTE STLW SCTK NSWG HHDC SHEE DAGV ECSV
Gene ID:8685
Uniprot:Q9UEW3
Cellular Location:Membrane, Single-pass type II membrane protein
Calculated MW:43kDa/52kDa
Observed MW:60kDa
Synonyms:MARCO, SCARA2, SR-A6
Background:The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.
UniProt Protein Function:MARCO: Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q14.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:pattern recognition receptor activity; transmembrane receptor activity

Biological Process: cell surface receptor linked signal transduction; receptor-mediated endocytosis

NCBI Summary:The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UEW3
NCBI GenInfo Identifier:17380151
NCBI Gene ID:8685
NCBI Accession:Q9UEW3.1
UniProt Secondary Accession:Q9UEW3,Q9Y5S3, B4DW79,
UniProt Related Accession:Q9UEW3
Molecular Weight:43,865 Da
NCBI Full Name:Macrophage receptor MARCO
NCBI Synonym Full Names:macrophage receptor with collagenous structure
NCBI Official Symbol:MARCO  
NCBI Official Synonym Symbols:SCARA2  
NCBI Protein Information:macrophage receptor MARCO
UniProt Protein Name:Macrophage receptor MARCO
UniProt Synonym Protein Names:Macrophage receptor with collagenous structure; Scavenger receptor class A member 2
Protein Family:Macrophage receptor
UniProt Gene Name:MARCO  
UniProt Entry Name:MARCO_HUMAN
Anti-MARCO Antibody (CAB10048)Western blot analysis of extracts of various cell lines, using MARCO antibody (CAB10048) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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