Cell Biology Antibodies 3

Anti-MAPKBP1 Antibody (CAB12576)

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SKU:
CAB12576
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MAPKBP1 Antibody
Antibody SKU:CAB12576
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAPKBP1 (NP_001122080.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-87MG, Mouse liver, Mouse lung
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MAPKBP1 (NP_001122080.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAVE GSTI TSRI KNLL RSPS IKLR RSKA GNRR EDLS SKVT LEKV LGIT VSGG RGLA CDPR SGLV AYPA GCVV VLFN PRKH KQHH ILNS SRKT ITAL AFSP
Gene ID:23005
Uniprot:O60336
Cellular Location:
Calculated MW:23kDa/109kDa/134kDa/149kDa/163kDa
Observed MW:164kDa
Synonyms:MAPKBP1, JNKBP-1, JNKBP1, NPHP20
Background:This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.
UniProt Protein Function:MAPKBP1: Involved in JNK signaling pathway. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 15q15.1

UniProt Code:O60336
NCBI GenInfo Identifier:215274254
NCBI Gene ID:23005
NCBI Accession:O60336.4
UniProt Secondary Accession:O60336,Q14CB5, Q14CD8, Q49AJ8, Q5W9G9, A6NM93, A8K8P9
UniProt Related Accession:O60336
Molecular Weight:Calculated MW: 23kDa/109kDa/134kDa/149kDa/163kDaObserved MW: 164kDa
NCBI Full Name:Mitogen-activated protein kinase-binding protein 1
NCBI Synonym Full Names:mitogen-activated protein kinase binding protein 1
NCBI Official Symbol:MAPKBP1  
NCBI Official Synonym Symbols:JNKBP-1  
NCBI Protein Information:mitogen-activated protein kinase-binding protein 1; JNK-binding protein 1; mitogen activated protein kinase binding protein 1
UniProt Protein Name:Mitogen-activated protein kinase-binding protein 1
UniProt Synonym Protein Names:JNK-binding protein 1; JNKBP-1
Protein Family:Mitogen-activated protein kinase-binding protein
UniProt Gene Name:MAPKBP1  
UniProt Entry Name:MABP1_HUMAN
Anti-MAPKBP1 Antibody (CAB12576)Western blot analysis of extracts of various cell lines, using MAPKBP1 antibody (CAB12576) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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