Cell Biology Antibodies 18

Anti-MAPK8IP3 Antibody (CAB18426)

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SKU:
CAB18426
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MAPK8IP3 Antibody
Antibody SKU:CAB18426
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human MAPK8IP3.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant protein of human MAPK8IP3.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:23162
Uniprot:Q9UPT6
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:JIP-3, JIP3, JSAP1, SYD2, syd, MAPK8IP3
Background:
UniProt Protein Function:JIP3: a member of the JNK-interacting protein group of scaffold proteins that selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies in the mouse suggested that this protein may interact with and regulate the activity of numerous protein kinases of the JNK signaling pathway. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: Golgi membrane; smooth endoplasmic reticulum; dendrite; cytoplasm; axolemma

Molecular Function:JUN kinase binding; MAP-kinase scaffold activity; receptor signaling complex scaffold activity; mitogen-activated protein kinase kinase binding; kinesin binding; mitogen-activated protein kinase kinase kinase binding

Biological Process: vesicle-mediated transport; axon guidance; protein localization; regulation of gene expression; in utero embryonic development; forebrain development; respiratory gaseous exchange; positive regulation of neuron differentiation; regulation of JNK cascade; alveolus development; activation of JNK activity; post-embryonic development

NCBI Summary:The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UPT6
NCBI GenInfo Identifier:145559484
NCBI Gene ID:23162
NCBI Accession:Q9UPT6.3
UniProt Secondary Accession:Q9UPT6,Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0, A2A2B3, A7E2B3
UniProt Related Accession:Q9UPT6
Molecular Weight:29,052 Da
NCBI Full Name:C-Jun-amino-terminal kinase-interacting protein 3
NCBI Synonym Full Names:mitogen-activated protein kinase 8 interacting protein 3
NCBI Official Symbol:MAPK8IP3  
NCBI Official Synonym Symbols:syd; JIP3; SYD2; JSAP1  
NCBI Protein Information:C-Jun-amino-terminal kinase-interacting protein 3; JIP-3; JNK-interacting protein 3; JNK/SAPK-associated protein-1; JNK MAP kinase scaffold protein 3; homolog of Drosophila Sunday driver 2; C-jun-amino-terminal kinase interacting protein 3; JNK/stress-activated protein kinase-associated protein 1; mitogen-activated protein kinase 8-interacting protein 3
UniProt Protein Name:C-Jun-amino-terminal kinase-interacting protein 3
UniProt Synonym Protein Names:JNK MAP kinase scaffold protein 3; Mitogen-activated protein kinase 8-interacting protein 3
Protein Family:C-Jun-amino-terminal kinase-interacting protein
UniProt Gene Name:MAPK8IP3  
UniProt Entry Name:JIP3_HUMAN
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