Cell Biology Antibodies 9
Anti-MAP7 Antibody (CAB4267)
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- SKU:
- CAB4267
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MAP7 Antibody |
| Antibody SKU: | CAB4267 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 490-749 of human MAP7 (NP_003971.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-431 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 490-749 of human MAP7 (NP_003971.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AREQ REKE ERER REQE ELER QKRE ELAQ RVAE ERTT RREE ESRR LEAE QARE KEEQ LQRQ AEER ALRE REEA ERAQ RQKE EEAR VREE AERV RQER EKHF QREE QERL ERKK RLEE IMKR TRRT EATD KKTS DQRN GDIA KGAL TGGT EVSA LPCT TNAP GNGK PVGS PHVV TSHQ SKVT VEST PDLE KQPN ENGV SVQN ENFE EIIN LPIG SKPS RLDV TNSE SPEI PLNP ILAF DDEG TLGP LPQV DGVQ TQQT AEVI |
| Gene ID: | 9053 |
| Uniprot: | Q14244 |
| Cellular Location: | Basolateral cell membrane, Cytoplasm, cytoskeleton, perinuclear region |
| Calculated MW: | 66kDa/72kDa/79kDa/82kDa/84kDa/86kDa |
| Observed MW: | 120kDa |
| Synonyms: | MAP7, E-MAP-115, EMAP115, ensconsin |
| Background: | The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | MAP7: Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. Belongs to the MAP7 family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Microtubule-binding Chromosomal Location of Human Ortholog: 6q23.3 Cellular Component: microtubule cytoskeleton; microtubule; microtubule associated complex; basolateral plasma membrane; perinuclear region of cytoplasm; cytoplasm Molecular Function:structural molecule activity; receptor binding Biological Process: establishment and/or maintenance of cell polarity; microtubule cytoskeleton organization and biogenesis; response to osmotic stress |
| NCBI Summary: | The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] |
| UniProt Code: | Q14244 |
| NCBI GenInfo Identifier: | 74739817 |
| NCBI Gene ID: | 9053 |
| NCBI Accession: | Q14244.1 |
| UniProt Secondary Accession: | Q14244,O88735, |
| UniProt Related Accession: | Q14244 |
| Molecular Weight: | 749 |
| NCBI Full Name: | Ensconsin |
| NCBI Synonym Full Names: | microtubule-associated protein 7 |
| NCBI Official Symbol: | MAP7 |
| NCBI Official Synonym Symbols: | EMAP115; E-MAP-115 |
| NCBI Protein Information: | ensconsin; MAP-7; epithelial microtubule-associated protein of 115 kDa; dJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP-115)) |
| UniProt Protein Name: | Ensconsin |
| UniProt Synonym Protein Names: | Epithelial microtubule-associated protein of 115 kDa; E-MAP-115; Microtubule-associated protein 7; MAP-7 |
| Protein Family: | MAP7 domain-containing protein |
| UniProt Gene Name: | MAP7 |
| UniProt Entry Name: | MAP7_HUMAN |
 | Western blot analysis of extracts of A-431 cells, using MAP7 antibody (CAB4267) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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