Signal Transduction Antibodies 3
Anti-MAP4 Antibody (CAB5906)
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- SKU:
- CAB5906
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-MAP4 Antibody |
| Antibody SKU: | CAB5906 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 942-1152 of human MAP4 (NP_002366.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-87MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 942-1152 of human MAP4 (NP_002366.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TENI KHQP GGGR AKVE KKTE AAAT TRKP ESNA VTKT AGPI ASAQ KQPA GKVQ IVSK KVSY SHIQ SKCG SKDN IKHV PGGG NVQI QNKK VDIS KVSS KCGS KANI KHKP GGGD VKIE SQKL NFKE KAQA KVGS LDNV GHLP AGGA VKTE GGGS EAPL CPGP PAGE EPAI SEAA PEAG APTS ASGL NGHP TLSG GGDQ REAQ TLDS QIQE TSI |
| Gene ID: | 4134 |
| Uniprot: | P27816 |
| Cellular Location: | Cytoplasm, cytoskeleton |
| Calculated MW: | 10kDa/58kDa/85kDa/91kDa/102kDa/119kDa/121kDa |
| Observed MW: | 200kDa |
| Synonyms: | MAP4 |
| Background: | The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. |
| NCBI Summary: | The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| UniProt Code: | P27816 |
| NCBI GenInfo Identifier: | 33870800 |
| NCBI Gene ID: | 4134 |
| NCBI Accession: | BC008715 |
| UniProt Secondary Accession: | P27816,Q13082, Q59FT2, Q68D74, Q6ZUW9, Q86V26, Q96A76 Q96NS9, |
| UniProt Related Accession: | P27816 |
| Molecular Weight: | 10,441 Da |
| NCBI Full Name: | Homo sapiens microtubule-associated protein 4, mRNA |
| NCBI Synonym Full Names: | microtubule associated protein 4 |
| NCBI Official Symbol: | MAP4 |
| NCBI Protein Information: | microtubule-associated protein 4 |
| UniProt Protein Name: | Microtubule-associated protein 4 |
| Protein Family: | Microtubule-associated protein |
| UniProt Gene Name: | MAP4 |
| UniProt Entry Name: | MAP4_HUMAN |
 | Western blot analysis of extracts of U-87MG cells, using MAP4 antibody (CAB5906) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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