Cell Biology Antibodies 5

Anti-MAP3K2 Antibody (CAB15135)

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SKU:
CAB15135
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MAP3K2 Antibody
Antibody SKU:CAB15135
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human MAP3K2 (NP_006600.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human MAP3K2 (NP_006600.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDDQ QALN SIMQ DLAV LHKA SRPA LSLQ ETRK AKSS SPKK QNDV RVKF EHRG EKRI LQFP RPVK LEDL RSKA KIAF GQSM DLHY TNNE LVIP LTTQ DDLD KAVE LLDR SIHM KSLK ILLV INGS TQAT NLEP LPSL EDLD NTVF GAER KKRL SIIG PTSR DRSS PPPG YIPD ELHQ VARN
Gene ID:10746
Uniprot:Q9Y2U5
Cellular Location:Cytoplasm, Nucleus
Calculated MW:69kDa
Observed MW:80kDa
Synonyms:MAP3K2, MEKK2, MEKK2B
Background:The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.
UniProt Protein Function:MEKK2: a protein kinase of the STE11 family. Phosphorylates and activates MEK5. Involved in growth factor stimulated cell proliferation and differentiation.
UniProt Protein Details:

Protein type:Kinase, protein; Protein kinase, STE; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family

Chromosomal Location of Human Ortholog: 2q14.3

Cellular Component: nucleoplasm; cytoplasm; cytosol

Molecular Function:MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; metal ion binding; protein kinase binding; ATP binding; protein kinase activity

Biological Process: activation of MAPKK activity; activation of MAPK activity; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; activation of JNK activity

NCBI Summary:The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y2U5
NCBI GenInfo Identifier:97536681
NCBI Gene ID:10746
NCBI Accession:Q9Y2U5.2
UniProt Related Accession:Q9Y2U5
Molecular Weight:70kDa
NCBI Full Name:Mitogen-activated protein kinase kinase kinase 2
NCBI Synonym Full Names:mitogen-activated protein kinase kinase kinase 2
NCBI Official Symbol:MAP3K2  
NCBI Official Synonym Symbols:MEKK2; MEKK2B  
NCBI Protein Information:mitogen-activated protein kinase kinase kinase 2
UniProt Protein Name:Mitogen-activated protein kinase kinase kinase 2
UniProt Synonym Protein Names:MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2
UniProt Gene Name:MAP3K2  
UniProt Entry Name:M3K2_HUMAN
Anti-MAP3K2 Antibody (CAB15135)Western blot analysis of extracts of mouse liver, using MAP3K2 antibody (CAB15135) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90.
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