Cell Biology Antibodies 5
Anti-MAP3K2 Antibody (CAB15135)
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- SKU:
- CAB15135
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MAP3K2 Antibody |
| Antibody SKU: | CAB15135 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human MAP3K2 (NP_006600.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human MAP3K2 (NP_006600.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDDQ QALN SIMQ DLAV LHKA SRPA LSLQ ETRK AKSS SPKK QNDV RVKF EHRG EKRI LQFP RPVK LEDL RSKA KIAF GQSM DLHY TNNE LVIP LTTQ DDLD KAVE LLDR SIHM KSLK ILLV INGS TQAT NLEP LPSL EDLD NTVF GAER KKRL SIIG PTSR DRSS PPPG YIPD ELHQ VARN |
| Gene ID: | 10746 |
| Uniprot: | Q9Y2U5 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 69kDa |
| Observed MW: | 80kDa |
| Synonyms: | MAP3K2, MEKK2, MEKK2B |
| Background: | The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. |
| UniProt Protein Function: | MEKK2: a protein kinase of the STE11 family. Phosphorylates and activates MEK5. Involved in growth factor stimulated cell proliferation and differentiation. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, STE; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family Chromosomal Location of Human Ortholog: 2q14.3 Cellular Component: nucleoplasm; cytoplasm; cytosol Molecular Function:MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; metal ion binding; protein kinase binding; ATP binding; protein kinase activity Biological Process: activation of MAPKK activity; activation of MAPK activity; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; activation of JNK activity |
| NCBI Summary: | The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y2U5 |
| NCBI GenInfo Identifier: | 97536681 |
| NCBI Gene ID: | 10746 |
| NCBI Accession: | Q9Y2U5.2 |
| UniProt Related Accession: | Q9Y2U5 |
| Molecular Weight: | 70kDa |
| NCBI Full Name: | Mitogen-activated protein kinase kinase kinase 2 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase 2 |
| NCBI Official Symbol: | MAP3K2 |
| NCBI Official Synonym Symbols: | MEKK2; MEKK2B |
| NCBI Protein Information: | mitogen-activated protein kinase kinase kinase 2 |
| UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase 2 |
| UniProt Synonym Protein Names: | MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2 |
| UniProt Gene Name: | MAP3K2 |
| UniProt Entry Name: | M3K2_HUMAN |
 | Western blot analysis of extracts of mouse liver, using MAP3K2 antibody (CAB15135) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90. |
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