Cell Biology Antibodies 1

Anti-MAP3K13 Antibody (CAB10189)

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SKU:
CAB10189
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MAP3K13 Antibody
Antibody SKU:CAB10189
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 500-759 of human MAP3K13 (NP_001229246.1).
Application:WB
Recommended Dilution:WB 1:1000 - 1:3000
Reactivity:Human, Mouse
Positive Samples:BxPC-3, U-87MG, LO2, BT-474, Mouse kidney, Mouse pancreas
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 500-759 of human MAP3K13 (NP_001229246.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CWRS SEPD KGQA GPWG CCQA DAYD PCLQ CRPE QYGS LDIP SAEP VGRS PDLS KSPA HNPL LENA QSSE KTEE NEFS GCRS ESSL GTSH LGTP PALP RKTR PLQK SGDD SSEE EEGE VDSE VEFP RRQR PHRC ISSC QSYS TFSS ENFS VSDG EEGN TSDH SNSP DELA DKLE DRLA EKLD DLLS QTPE IPID ISSH SDGL SDKE CAVR RVKT QMSL GKLC VEER GYEN PMQF EESD CDSS DGEC SDAT VRTN KHYS SATW
Gene ID:9175
Uniprot:O43283
Cellular Location:Cytoplasm, Membrane, Peripheral membrane protein
Calculated MW:14kDa/17kDa/85kDa/92kDa/108kDa
Observed MW:108kDa
Synonyms:MAP3K13, LZK, MEKK13, MLK
Background:The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.
UniProt Protein Function:LZK: a TKL kinase of the MLK family. Synergizes with antioxidant protein-1 to activate NF-kappaB. Forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. This kinase can phosphorylate and activate JNK and MKK7. Contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif.
UniProt Protein Details:

Protein type:EC 2.7.11.25; Kinase, protein; LZK subfamily; MLK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group

Chromosomal Location of Human Ortholog: 3q27.2

Cellular Component: IkappaB kinase complex; membrane

Molecular Function:identical protein binding; MAP kinase kinase kinase activity; protein binding; protein homodimerization activity; protein kinase binding; protein serine/threonine kinase activity

Biological Process: activation of MAPKK activity; activation of NF-kappaB transcription factor; JNK cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation

NCBI Summary:The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]
UniProt Code:O43283
NCBI GenInfo Identifier:68052263
NCBI Gene ID:9175
NCBI Accession:O43283.1
UniProt Secondary Accession:O43283,Q05BY6, Q15450, Q2NKN3, B2R6U2, B4DLE3, B4DMV2 B4DZJ4, D3DNU1,
UniProt Related Accession:O43283
Molecular Weight:108kDa
NCBI Full Name:Mitogen-activated protein kinase kinase kinase 13
NCBI Synonym Full Names:mitogen-activated protein kinase kinase kinase 13
NCBI Official Symbol:MAP3K13  
NCBI Official Synonym Symbols:LZK; MLK; MEKK13  
NCBI Protein Information:mitogen-activated protein kinase kinase kinase 13
UniProt Protein Name:Mitogen-activated protein kinase kinase kinase 13
UniProt Synonym Protein Names:Leucine zipper-bearing kinase; Mixed lineage kinase; MLK
Protein Family:Mitogen-activated protein kinase kinase kinase
UniProt Gene Name:MAP3K13  
Anti-MAP3K13 Antibody (CAB10189)Western blot analysis of extracts of various cell lines, using MAP3K13 antibody (CAB10189) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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