Cell Biology Antibodies 6
Anti-MAP3K11 Antibody (CAB16242)
- SKU:
- CAB16242
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MAP3K11 Antibody |
| Antibody SKU: | CAB16242 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-260 of human MAP3K11 (NP_002410.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-260 of human MAP3K11 (NP_002410.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LVAV KAAR QDPD EDIS VTAE SVRQ EARL FAML AHPN IIAL KAVC LEEP NLCL VMEY AAGG PLSR ALAG RRVP PHVL VNWA VQIA RGMH YLHC EALV PVIH RDLK SNNI LLLQ PIES DDME H |
| Gene ID: | 4296 |
| Uniprot: | Q16584 |
| Cellular Location: | |
| Calculated MW: | 65kDa/92kDa |
| Observed MW: | Refer to figures |
| Synonyms: | MAP3K11, MEKK11, MLK-3, MLK3, PTK1, SPRK |
| Background: | The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. |
| UniProt Protein Function: | MLK3: a TKL kinase of the MLK family. Has an amino-terminal SH3 domain followed by the kinase domain, two leucine zipper domains, a cdc42/Rac1 binding (CRIB) domain and several other domains/motifs at the carboxy-terminal region. Phosphorylates IkappaB and activates SEK1 and MKK7. |
| UniProt Protein Details: | Protein type:EC 2.7.11.25; Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; MLK subfamily Chromosomal Location of Human Ortholog: 11q13.1-q13.3 Cellular Component: centrosome; cytoplasm; membrane; microtubule Molecular Function:ATP binding; identical protein binding; JUN kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; Rac GTPase binding Biological Process: activation of JNK activity; activation of JNKK activity; activation of MAPK activity; cell death; cell proliferation; JNK cascade; microtubule-based process; peptidyl-tyrosine phosphorylation; positive regulation of JNK activity; positive regulation of JNK cascade; positive regulation of neuron apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation |
| NCBI Summary: | The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16584 |
| NCBI GenInfo Identifier: | 71153819 |
| NCBI Gene ID: | 4296 |
| NCBI Accession: | Q16584.1 |
| UniProt Secondary Accession: | Q16584,Q53H00, Q59F06, Q6P2G4, B4DS76, |
| UniProt Related Accession: | Q16584 |
| Molecular Weight: | 65,344 Da |
| NCBI Full Name: | Mitogen-activated protein kinase kinase kinase 11 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase 11 |
| NCBI Official Symbol: | MAP3K11 |
| NCBI Official Synonym Symbols: | MLK3; PTK1; SPRK; MLK-3; MEKK11 |
| NCBI Protein Information: | mitogen-activated protein kinase kinase kinase 11 |
| UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase 11 |
| UniProt Synonym Protein Names: | Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase |
| UniProt Gene Name: | MAP3K11 |
| UniProt Entry Name: | M3K11_HUMAN |
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