Cell Biology Antibodies 6
Anti-MAOB Antibody (CAB1568)
- SKU:
- CAB1568
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MAOB Antibody |
| Antibody SKU: | CAB1568 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MAOB (NP_000889.3). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MAOB (NP_000889.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSNK CDVV VVGG GISG MAAA KLLH DSGL NVVV LEAR DRVG GRTY TLRN QKVK YVDL GGSY VGPT QNRI LRLA KELG LETY KVNE VERL IHHV KGKS YPFR GPFP PVWN PITY LDHN NFWR TMDD MGRE IPSD APWK APLA EEWD NMTM KELL DKLC WTES AKQL ATLF VNLC VTAE THEV SALW FLWY VKQC GGTT RIIS TTNG GQER KFVG GSGQ VSER IMDL LGDR VKLE RPVI YIDQ TREN VLVE TLNH EMYE AKYV |
| Gene ID: | 4129 |
| Uniprot: | P27338 |
| Cellular Location: | Cytoplasmic side, Mitochondrion outer membrane, Single-pass type IV membrane protein |
| Calculated MW: | 46kDa/58kDa |
| Observed MW: | 60KDa |
| Synonyms: | MAOB |
| Background: | The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. |
| UniProt Protein Function: | MAOB: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. Belongs to the flavin monoamine oxidase family. |
| UniProt Protein Details: | Protein type:Mitochondrial; Amino Acid Metabolism - arginine and proline; EC 1.4.3.4; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - histidine; Membrane protein, integral; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Oxidoreductase; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tryptophan Chromosomal Location of Human Ortholog: Xp11.23 Cellular Component: mitochondrial envelope; mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; integral to membrane Molecular Function:amine oxidase activity; protein homodimerization activity; electron carrier activity; FAD binding Biological Process: response to drug; negative regulation of serotonin secretion; positive regulation of dopamine metabolic process; response to selenium ion; response to ethanol; substantia nigra development; dopamine catabolic process; response to toxin; xenobiotic metabolic process; response to lipopolysaccharide; hydrogen peroxide biosynthetic process; response to corticosterone stimulus; response to aluminum ion |
| NCBI Summary: | The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P27338 |
| NCBI GenInfo Identifier: | 113980 |
| NCBI Gene ID: | 4129 |
| NCBI Accession: | P27338.3 |
| UniProt Secondary Accession: | P27338,Q7Z6S2, B2R6R3, B7Z5H3, D3DWC3, |
| UniProt Related Accession: | P27338 |
| Molecular Weight: | 520 |
| NCBI Full Name: | Amine oxidase |
| NCBI Synonym Full Names: | monoamine oxidase B |
| NCBI Official Symbol: | MAOB |
| NCBI Protein Information: | amine oxidase [flavin-containing] B; amine oxidase [flavin-containing] B; MAO-B; MAO, brain; MAO, platelet; tyramine oxidase; adrenalin oxidase; monoamine oxidase type B |
| UniProt Protein Name: | Amine oxidase [flavin-containing] B |
| UniProt Synonym Protein Names: | Monoamine oxidase type B; MAO-B |
| Protein Family: | Amine oxidase |
| UniProt Gene Name: | MAOB |
| UniProt Entry Name: | AOFB_HUMAN |
 | Western blot analysis of extracts of HeLa cells, using MAOB antibody (CAB1568) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded human colon using MAOB Rabbit pAb (CAB1568) at dilution of 100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using MAOB Rabbit pAb (CAB1568) at dilution of 100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat lung using MAOB Rabbit pAb (CAB1568) at dilution of 100 (40x lens). |
 | Immunofluorescence analysis of L929 cells using MAOB Rabbit pAb (CAB1568) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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