Metabolism Antibodies 1
Anti-MAOA Antibody (CAB1354)
- SKU:
- CAB1354
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-MAOA Antibody |
| Antibody SKU: | CAB1354 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MAOA (NP_000231.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, PC-3, HeLa, HT-29, Mouse lung, Mouse intestine, Mouse kidney, Mouse liver, NCI-H460 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MAOA (NP_000231.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MENQ EKAS IAGH MFDV VVIG GGIS GLSA AKLL TEYG VSVL VLEA RDRV GGRT YTIR NEHV DYVD VGGA YVGP TQNR ILRL SKEL GIET YKVN VSER LVQY VKGK TYPF RGAF PPVW NPIA YLDY NNLW RTID NMGK EIPT DAPW EAQH ADKW DKMT MKEL IDKI CWTK TARR FAYL FVNI NVTS EPHE VSAL WFLW YVKQ CGGT TRIF SVTN GGQE RKFV GGSG QVSE RIMD LLGD QVKL NHPV THVD QSSD NIII ETLN |
| Gene ID: | 4128 |
| Uniprot: | P21397 |
| Cellular Location: | Cytoplasmic side, Mitochondrion outer membrane, Single-pass type IV membrane protein |
| Calculated MW: | 44kDa/59kDa |
| Observed MW: | 65kDa |
| Synonyms: | MAOA, BRNRS, MAO-A |
| Background: | This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. |
| UniProt Protein Function: | MAOA: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are the cause of Brunner syndrome (BRUNS). Brunner syndrome is a form of X-linked non- dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Belongs to the flavin monoamine oxidase family. |
| UniProt Protein Details: | Protein type:EC 1.4.3.4; Membrane protein, integral; Amino Acid Metabolism - tryptophan; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - histidine; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - glycine, serine and threonine; Oxidoreductase; Amino Acid Metabolism - tyrosine Chromosomal Location of Human Ortholog: Xp11.3 Cellular Component: mitochondrial outer membrane; mitochondrion; integral to membrane Molecular Function:amine oxidase activity Biological Process: synaptic transmission; biogenic amine metabolic process; neurotransmitter catabolic process; dopamine catabolic process; xenobiotic metabolic process; neurotransmitter secretion; neurotransmitter biosynthetic process Disease: Brunner Syndrome |
| NCBI Summary: | This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012] |
| UniProt Code: | P21397 |
| NCBI GenInfo Identifier: | 113978 |
| NCBI Gene ID: | 4128 |
| NCBI Accession: | P21397.1 |
| UniProt Secondary Accession: | P21397,Q16426, B4DF46, |
| UniProt Related Accession: | P21397 |
| Molecular Weight: | 527 |
| NCBI Full Name: | Amine oxidase |
| NCBI Synonym Full Names: | monoamine oxidase A |
| NCBI Official Symbol: | MAOA |
| NCBI Official Synonym Symbols: | MAO-A |
| NCBI Protein Information: | amine oxidase [flavin-containing] A; amine oxidase [flavin-containing] A; monoamine oxidase type A |
| UniProt Protein Name: | Amine oxidase [flavin-containing] A |
| UniProt Synonym Protein Names: | Monoamine oxidase type A; MAO-A |
| Protein Family: | Amine oxidase |
| UniProt Gene Name: | MAOA |
| UniProt Entry Name: | AOFA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MAOA antibody (CAB1354) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded rat brain using MAOA antibody (CAB1354) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human thyroid cancer using MAOA antibody (CAB1354) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using MAOA antibody (CAB1354) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of C6 cells using MAOA antibody (CAB1354) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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