Cell Biology Antibodies 2
Anti-MAN1A1 Antibody (CAB10830)
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- SKU:
- CAB10830
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MAN1A1 Antibody |
| Antibody SKU: | CAB10830 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 70-190 of human MAN1A1 (NP_005898.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, LO2, Raji, A-549 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 70-190 of human MAN1A1 (NP_005898.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SGVL FHSS PALQ PAAD HKPG PGAR AEDA AEGR ARRR EEGA PGDP EAAL EDNL ARIR ENHE RALR EAKE TLQK LPEE IQRD ILLE KKKV AQDQ LRDK APFR GLPP VDFV PPIG VESR EPAD A |
| Gene ID: | 4121 |
| Uniprot: | P33908 |
| Cellular Location: | Golgi apparatus membrane, Single-pass type II membrane protein |
| Calculated MW: | 40kDa/72kDa |
| Observed MW: | 73kDa |
| Synonyms: | MAN1A1, HUMM3, HUMM9, MAN9 |
| Background: | This gene encodes a class I mammalian Golgi 1, 2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. |
| UniProt Protein Function: | MAN1A1: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). Belongs to the glycosyl hydrolase 47 family. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum; Calcium-binding; EC 3.2.1.113; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; Hydrolase Chromosomal Location of Human Ortholog: 6q22 Cellular Component: Golgi membrane; Golgi apparatus; membrane; endoplasmic reticulum; cytoplasm; ER-Golgi intermediate compartment; integral to membrane Molecular Function:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; calcium ion binding; mannosidase activity Biological Process: cellular protein metabolic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification |
| NCBI Summary: | This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012] |
| UniProt Code: | P33908 |
| NCBI GenInfo Identifier: | 62906886 |
| NCBI Gene ID: | 4121 |
| NCBI Accession: | P33908.3 |
| UniProt Secondary Accession: | P33908,P45700, |
| UniProt Related Accession: | P33908 |
| Molecular Weight: | 72,969 Da |
| NCBI Full Name: | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA |
| NCBI Synonym Full Names: | mannosidase, alpha, class 1A, member 1 |
| NCBI Official Symbol: | MAN1A1 |
| NCBI Official Synonym Symbols: | MAN9; HUMM3; HUMM9 |
| NCBI Protein Information: | mannosyl-oligosaccharide 1,2-alpha-mannosidase IA; Man9-mannosidase; alpha-1,2-mannosidase IA; man(9)-alpha-mannosidase; processing alpha-1,2-mannosidase IA |
| UniProt Protein Name: | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA |
| UniProt Synonym Protein Names: | Man(9)-alpha-mannosidase; Man9-mannosidase; Mannosidase alpha class 1A member 1; Processing alpha-1,2-mannosidase IA |
| Protein Family: | Mannosyl-oligosaccharide 1,2-alpha-mannosidase |
| UniProt Gene Name: | MAN1A1 |
| UniProt Entry Name: | MA1A1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MAN1A1 antibody (CAB10830) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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