Cell Biology Antibodies 13

Anti-MAML2 Antibody (CAB17225)

(No reviews yet) Write a Review
SKU:
CAB17225
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-MAML2 Antibody
Antibody SKU:CAB17225
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 750-850 of human MAML2 (NP_115803.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, 293T, Mouse brain, Mouse lung
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 750-850 of human MAML2 (NP_115803.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NQQL MGKK QTLQ RQIM EQKQ QLLL QQQM LADA EKIA PQDQ INRH LSRP PPDY KDQR RNVG NMQP TAQY SGGS STIS LNSN QALA NPVS THTI LTPN SSLL S
Gene ID:84441
Uniprot:Q8IZL2
Cellular Location:
Calculated MW:
Observed MW:150kDa
Anti-MAML2 Antibody (CAB17225)Western blot - MAML2 Rabbit pAb (CAB17225)
Synonyms:MAML2, MAM-3, MAM2, MAM3, MLL-MAML2
Background:The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed.
UniProt Protein Function:MAML2: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. Interacts through its N-terminal region with the ankyrin repeat region of the Notch proteins NOTCH1, NOTCH2, NOTCH3 and NOTCH4. Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa. Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle. Belongs to the mastermind family.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 11q21

Cellular Component: Golgi apparatus; nucleoplasm; nucleus

Molecular Function:transcription coactivator activity

Biological Process: activation of Notch receptor target transcription factor; Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter

NCBI Summary:The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]
UniProt Code:Q8IZL2
NCBI GenInfo Identifier:296435513
NCBI Gene ID:84441
NCBI Accession:Q8IZL2.2
UniProt Secondary Accession:Q8IZL2,Q6AI23, Q6Y3A3, Q8IUL3, Q96JK6, A7MD26,
UniProt Related Accession:Q8IZL2
Molecular Weight:125,197 Da
NCBI Full Name:Mastermind-like protein 2
NCBI Synonym Full Names:mastermind like transcriptional coactivator 2
NCBI Official Symbol:MAML2  
NCBI Official Synonym Symbols:MAM2; MAM3; MAM-3; MLL-MAML2  
NCBI Protein Information:mastermind-like protein 2
UniProt Protein Name:Mastermind-like protein 2
Protein Family:Mastermind-like protein
UniProt Gene Name:MAML2  
UniProt Entry Name:MAML2_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products