Cell Biology Antibodies 13

Anti-MAK Antibody (CAB17508)

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SKU:
CAB17508
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MAK Antibody
Antibody SKU:CAB17508
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 370-435 of human MAK (NP_005897.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse lung, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 370-435 of human MAK (NP_005897.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TLFP SIVK NMPT KPNG TLSH KSGR RRWG QTIF KSGD SWEE LEDY DFGA SHSK KPSM GVFK EKRK KD
Gene ID:4117
Uniprot:P20794
Cellular Location:
Calculated MW:
Observed MW:71kDa
Anti-MAK Antibody (CAB17508)Western blot - MAK Polyclonal Antibody (CAB17508)
Synonyms:RP62, MAK
Background:The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. Mutations in this gene have been associated with ciliary defects resulting in retinitis pigmentosa 62. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Protein Function:MAK: a protein kinase of the RCK family of kinases. It is expressed at high levels in the testis (primarily in germ cells), and in developing sensory epithelia. Localizes to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired.
UniProt Protein Details:

Protein type:Protein kinase, CMGC; EC 2.7.11.22; Nuclear receptor co-regulator; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CMGC group; RCK family

Chromosomal Location of Human Ortholog: 6p24

Cellular Component: centrosome; midbody; nucleus; photoreceptor inner segment; photoreceptor outer segment

Molecular Function:protein binding; transcription coactivator activity

Biological Process: photoreceptor cell maintenance; protein amino acid autophosphorylation; protein amino acid phosphorylation

Disease: Retinitis Pigmentosa 62

NCBI Summary:The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. Mutations in this gene have been associated with ciliary defects resulting in retinitis pigmentosa 62. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Code:P20794
NCBI GenInfo Identifier:13432166
NCBI Gene ID:4117
NCBI Accession:P20794.2
UniProt Secondary Accession:P20794,Q547D0, Q9NUH7, F1T0K6, G1FL29,
UniProt Related Accession:P20794
Molecular Weight:66,345 Da
NCBI Full Name:Serine/threonine-protein kinase MAK
NCBI Synonym Full Names:male germ cell associated kinase
NCBI Official Symbol:MAK  
NCBI Official Synonym Symbols:RP62  
NCBI Protein Information:serine/threonine-protein kinase MAK
UniProt Protein Name:Serine/threonine-protein kinase MAK
UniProt Synonym Protein Names:Male germ cell-associated kinase
Protein Family:Makatoxin
UniProt Gene Name:MAK  
UniProt Entry Name:MAK_HUMAN
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