Signal Transduction Antibodies 2

Anti-MAGT1 Antibody (CAB5039)

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SKU:
CAB5039
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MAGT1
Synonyms:
IAP
Synonyms:
MRX95
Synonyms:
OST3B
Synonyms:
PRO0756
Synonyms:
XMEN
Synonyms:
bA217H1.1

Description

Product Name:MAGT1 Rabbit pAb
Product Code:CAB5039
Size:20uL, 50uL, 100uL
Synonyms:MAGT1, IAP, MRX95, OST3B, PRO0756, XMEN, bA217H1.1
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-220 of human MAGT1 (NP_115497.4).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:1000
Reactivity:Human
Positive Samples:U-251MG
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 60-220 of human MAGT1 (NP_115497.4).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SAQR KKEM VLSE KVSQ LMEW TNKR PVIR MNGD KFRR LVKA PPRN YSVI VMFT ALQL HRQC VVCK QADE EFQI LANS WRYS SAFT NRIF FAMV DFDE GSDV FQML NMNS APTF INFP AKGK PKRG DTYE LQVR GFSA EQIA RWIA DRTD VNIR VIRP PNYA G
Gene ID:84061
Uniprot:Q9H0U3
Cellular Location:Cell membrane, Endoplasmic reticulum membrane, Multi-pass membrane protein
Calculated MW:15kDa/38kDa
Observed MW:50kDa
UniProt Protein Function:MAGT1: May be involved in N-glycosylation through its association with N-oligosaccharyl transferase. May be involved in Mg(2+) transport in epithelial cells. Defects in MAGT1 are the cause of mental retardation X- linked type 95 (MRX95). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation. Defects in MAGT1 are the cause of immunodeficiency X- linked with magnesium defect Epstein-Barr virus infection and neoplasia (XMEN). XMEN is a disease characterized by CD4 lymphopenia, severe chronic viral infections, and defective T- lymphocyte activation. Belongs to the OST3/OST6 family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq21.1

Cellular Component: membrane; oligosaccharyl transferase complex; plasma membrane

Molecular Function:magnesium ion transmembrane transporter activity

Biological Process: cognition; magnesium ion transport; protein amino acid N-linked glycosylation via asparagine; transmembrane transport

Disease: Immunodeficiency, X-linked, With Magnesium Defect, Epstein-barr Virus Infection, And Neoplasia

NCBI Summary:This gene encodes a magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause mental retardation X-linked type 95 (MRX95). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29. [provided by RefSeq, Jan 2010]
UniProt Code:Q9H0U3
NCBI GenInfo Identifier:74761391
NCBI Gene ID:84061
NCBI Accession:Q9H0U3.1
UniProt Secondary Accession:Q9H0U3,Q53G00, Q6P577, Q8NBN6, B2RAR4, D3DTE3,
UniProt Related Accession:Q9H0U3
Molecular Weight:15,699 Da
NCBI Full Name:Magnesium transporter protein 1
NCBI Synonym Full Names:magnesium transporter 1
NCBI Official Symbol:MAGT1  
NCBI Official Synonym Symbols:IAP; XMEN; MRX95; OST3B; PRO0756; bA217H1.1  
NCBI Protein Information:magnesium transporter protein 1
UniProt Protein Name:Magnesium transporter protein 1
UniProt Synonym Protein Names:Implantation-associated protein; IAP
Protein Family:Magnesium transporter protein
UniProt Gene Name:MAGT1  
UniProt Entry Name:MAGT1_HUMAN
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