Immunology Antibodies 3

Anti-MAGI3 Antibody (CAB9893)

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SKU:
CAB9893
Product Type:
Antibody
Applications:
WB
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology

Description

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Antibody Name:Anti-MAGI3 Antibody
Antibody SKU:CAB9893
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-105 of human MAGI3 (NP_001136254.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-105 of human MAGI3 (NP_001136254.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSKT LKKK KHWL SKVQ ECAV SWAG PPGD FGAE IRGG AERG EFPY LGRL REEP GGGT CCVV SGKA PSPG DVLL EVNG TPVS GLTN RDTL AVIR HFRE PIRL KTVK P
Gene ID:260425
Uniprot:Q5TCQ9
Cellular Location:Cell junction, Cell membrane, Nucleus, Peripheral membrane protein, tight junction
Calculated MW:123kDa/125kDa/162kDa/165kDa
Observed MW:200kDa
Synonyms:MAGI3, MAGI-3, dJ730K3.2
Background:
UniProt Protein Function:MAGI3: a protein of the MAGUK family of proteins. A peripheral membrane protein found at cell-cell junctions. Contains one guanylate kinase, two WW, and four PDZ domains. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. Interacts with ADRB1, FZD4, FZD7, PTPRB, TGFA and VANGL2. Interacts with BAI1, LPAR2/EDG4, GRIN2B and PTEN. In case of infection, interacts with HTLV TAX1 protein, possibly affecting the transformation ability of TAX1. Does not interact with HTLV TAX2 or TAX3 proteins. Interacts with HPV type 16 and HPV type 18 E6 protein. Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex. Four alternatively spliced human isoforms have been described.
UniProt Protein Details:

Protein type:Membrane protein, peripheral; Kinase, other

Chromosomal Location of Human Ortholog: 1p13.2

Molecular Function:protein binding

UniProt Code:Q5TCQ9
NCBI GenInfo Identifier:190359882
NCBI Gene ID:260425
NCBI Accession:Q5TCQ9.2
UniProt Secondary Accession:Q5TCQ9,Q5TCQ8, Q5TCR0, Q9H2V6, Q9H5Y8, Q9HBC4, Q9HCD8
UniProt Related Accession:Q5TCQ9
Molecular Weight:162,949 Da
NCBI Full Name:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
NCBI Synonym Full Names:membrane associated guanylate kinase, WW and PDZ domain containing 3
NCBI Official Symbol:MAGI3  
NCBI Official Synonym Symbols:MAGI-3; dJ730K3.2  
NCBI Protein Information:membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
UniProt Protein Name:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
UniProt Synonym Protein Names:Membrane-associated guanylate kinase inverted 3; MAGI-3
Protein Family:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein
UniProt Gene Name:MAGI3  
UniProt Entry Name:MAGI3_HUMAN
Anti-MAGI3 Polyclonal Antibody (CAB9893)Western blot analysis of extracts of mouse lung, using MAGI3 antibody (CAB9893) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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