Signal Transduction Antibodies 3
Anti-MAGEA6 Antibody (CAB8130)
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- SKU:
- CAB8130
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | MAGEA6 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8130 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 75-314 of human MAGEA6 (NP_005354.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 22Rv1, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 75-314 of human MAGEA6 (NP_005354.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNYP LWSQ SYED SSNQ EEEG PSTF PDLE SEFQ AALS RKVA KLVH FLLL KYRA REPV TKAE MLGS VVGN WQYF FPVI FSKA SDSL QLVF GIEL MEVD PIGH VYIF ATCL GLSY DGLL GDNQ IMPK TGFL IIIL AIIA KEGD CAPE EKIW EELS VLEV FEGR EDSI FGDP KKLL TQYF VQEN YLEY RQVP GSDP ACYE FLWG PRAL IETS YVKV LHHM VKIS GGPR ISYP LLHE WALR EGEE |
| Gene ID: | 4105 |
| Uniprot: | P43360 |
| Cellular Location: | |
| Calculated MW: | 34kDa |
| Observed MW: | 35kDa |
| Synonyms: | MAGEA6, CT1.6, MAGE-3b, MAGE3B, MAGE6 |
| Background: | This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. |
| NCBI Summary: | This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| UniProt Code: | P43360 |
| NCBI GenInfo Identifier: | 4885469 |
| NCBI Gene ID: | 4105 |
| NCBI Accession: | NP_005354.1 |
| UniProt Secondary Accession: | P43360,Q6NW44, A8IF93, |
| UniProt Related Accession: | P43360 |
| Molecular Weight: | 34 |
| NCBI Full Name: | melanoma-associated antigen 6 |
| NCBI Synonym Full Names: | MAGE family member A6 |
| NCBI Official Symbol: | MAGEA6 |
| NCBI Official Synonym Symbols: | CT1.6; MAGE6; MAGE3B; MAGE-3b |
| NCBI Protein Information: | melanoma-associated antigen 6 |
| UniProt Protein Name: | Melanoma-associated antigen 6 |
| UniProt Synonym Protein Names: | Cancer/testis antigen 1.6; CT1.6; MAGE-6 antigen; MAGE3B antigen |
| UniProt Gene Name: | MAGEA6 |
 | Western blot analysis of extracts of various cell lines, using MAGEA6 antibody (CAB8130) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using MAGEA6 antibody (CAB8130) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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