Cell Biology Antibodies 13
Anti-MAFK Antibody (CAB17551)
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- SKU:
- CAB17551
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MAFK Antibody |
| Antibody SKU: | CAB17551 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of Human MAFK. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | SGC-7901, LO2 |
| Immunogen: | A synthetic peptide of Human MAFK. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7975 |
| Uniprot: | O60675 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 17kDa |
 | Western blot - MAFK Polyclonal Antibody (CAB17551) |
| Synonyms: | NFE2U, P18, MAFK |
| Background: | The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008] |
| UniProt Protein Function: | MAFK: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Belongs to the bZIP family. Maf subfamily. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 7p22.3 Cellular Component: nucleoplasm Molecular Function:transcription factor activity Biological Process: nervous system development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; blood coagulation |
| NCBI Summary: | The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008] |
| UniProt Code: | O60675 |
| NCBI GenInfo Identifier: | 4505075 |
| NCBI Gene ID: | 7975 |
| NCBI Accession: | NP_002351.1 |
| UniProt Secondary Accession: | O60675,A4D214, |
| UniProt Related Accession: | O60675 |
| Molecular Weight: | 17,523 Da |
| NCBI Full Name: | transcription factor MafK |
| NCBI Synonym Full Names: | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K |
| NCBI Official Symbol: | MAFK |
| NCBI Official Synonym Symbols: | P18; NFE2U |
| NCBI Protein Information: | transcription factor MafK; nuclear factor erythroid-2, ubiquitous (p18); basic-leucine zipper transcription factor MafK; erythroid transcription factor NF-E2 p18 subunit; v-maf musculoaponeurotic fibrosarcoma oncogene homolog K; v-maf avian musculoaponeurotic fibrosarcoma oncogene family, protein K |
| UniProt Protein Name: | Transcription factor MafK |
| UniProt Synonym Protein Names: | Erythroid transcription factor NF-E2 p18 subunit |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | MAFK |
| UniProt Entry Name: | MAFK_HUMAN |
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