Metabolism Antibodies 1
Anti-MAFF Antibody (CAB12920)
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- SKU:
- CAB12920
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-MAFF Antibody |
| Antibody SKU: | CAB12920 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 75-164 of human MAFF (NP_036455.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HT-29 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 75-164 of human MAFF (NP_036455.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QKEE LQKQ KSEL EREV DKLA RENA AMRL ELDA LRGK CEAL QGFA RSVA AARG PATL VAPA SVIT IVKS TPGS GSGP AHGP DPAH GPAS CS |
| Gene ID: | 23764 |
| Uniprot: | Q9ULX9 |
| Cellular Location: | Nucleus |
| Calculated MW: | 14kDa/17kDa |
| Observed MW: | 18kDa |
| Synonyms: | MAFF, U-MAF, hMafF |
| Background: | The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. |
| UniProt Protein Function: | MAFF: Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. Since it lacks a putative transactivation domain, it may behave as a transcriptional repressor when it dimerize among himself. May also serve as a transcriptional activator by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. May be involved in the cellular stress response. Belongs to the bZIP family. Maf subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: mitochondrion; nucleoplasm; nucleus Biological Process: blood coagulation; parturition; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009] |
| UniProt Code: | Q9ULX9 |
| NCBI GenInfo Identifier: | 21542145 |
| NCBI Gene ID: | 23764 |
| NCBI Accession: | Q9ULX9.2 |
| UniProt Secondary Accession: | Q9ULX9,Q9Y525, B4DV49, |
| UniProt Related Accession: | Q9ULX9 |
| Molecular Weight: | 14,569 Da |
| NCBI Full Name: | Transcription factor MafF |
| NCBI Synonym Full Names: | MAF bZIP transcription factor F |
| NCBI Official Symbol: | MAFF |
| NCBI Official Synonym Symbols: | U-MAF; hMafF |
| NCBI Protein Information: | transcription factor MafF |
| UniProt Protein Name: | Transcription factor MafF |
| UniProt Synonym Protein Names: | U-Maf; V-maf musculoaponeurotic fibrosarcoma oncogene homolog F |
| Protein Family: | MaFF-interacting protein |
| UniProt Gene Name: | MAFF |
| UniProt Entry Name: | MAFF_HUMAN |
 | Western blot analysis of extracts of HT-29 cells, using MAFF antibody (CAB12920) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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