| UniProt Protein Function: | MXD3: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 5q35.3 Molecular Function:protein binding |
| NCBI Summary: | This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008] |
| UniProt Code: | Q9BW11 |
| NCBI GenInfo Identifier: | 74733390 |
| NCBI Gene ID: | 83463 |
| NCBI Accession: | Q9BW11.1 |
| UniProt Secondary Accession: | Q9BW11,Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3, B4E0J1, |
| UniProt Related Accession: | Q9BW11 |
| Molecular Weight: | 42,821 Da |
| NCBI Full Name: | Max dimerization protein 3 |
| NCBI Synonym Full Names: | MAX dimerization protein 3 |
| NCBI Official Symbol: | MXD3 |
| NCBI Official Synonym Symbols: | MYX; MAD3; BHLHC13 |
| NCBI Protein Information: | max dimerization protein 3 |
| UniProt Protein Name: | Max dimerization protein 3 |
| UniProt Synonym Protein Names: | Class C basic helix-loop-helix protein 13; bHLHc13; Max-associated protein 3; Max-interacting transcriptional repressor MAD3; Myx |
| Protein Family: | Max dimerization protein |
| UniProt Gene Name: | MXD3 |
| UniProt Entry Name: | MAD3_HUMAN |
