Anti-MAD3/MXD3 Antibody (CAB19807)
- SKU:
- CAB19807
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- BHLHC13
- Synonyms:
- MAD3
- Synonyms:
- MYX
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | MAD3/MXD3 Rabbit mAb |
| Product Code: | CAB19807 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | BHLHC13, MAD3, MYX |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human MAD3/MXD3 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, DU145, Jurkat |
| Immunogen: | A synthesized peptide derived from human MAD3/MXD3 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 83463 |
| Uniprot: | Q9BW11 |
| Calculated MW: | 28kDa |
| Observed MW: | 24KDa |
| UniProt Protein Function: | MXD3: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 5q35.3 Molecular Function:protein binding |
| NCBI Summary: | This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008] |
| UniProt Code: | Q9BW11 |
| NCBI GenInfo Identifier: | 74733390 |
| NCBI Gene ID: | 83463 |
| NCBI Accession: | Q9BW11.1 |
| UniProt Secondary Accession: | Q9BW11,Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3, B4E0J1, |
| UniProt Related Accession: | Q9BW11 |
| Molecular Weight: | 42,821 Da |
| NCBI Full Name: | Max dimerization protein 3 |
| NCBI Synonym Full Names: | MAX dimerization protein 3 |
| NCBI Official Symbol: | MXD3 |
| NCBI Official Synonym Symbols: | MYX; MAD3; BHLHC13 |
| NCBI Protein Information: | max dimerization protein 3 |
| UniProt Protein Name: | Max dimerization protein 3 |
| UniProt Synonym Protein Names: | Class C basic helix-loop-helix protein 13; bHLHc13; Max-associated protein 3; Max-interacting transcriptional repressor MAD3; Myx |
| Protein Family: | Max dimerization protein |
| UniProt Gene Name: | MXD3 |
| UniProt Entry Name: | MAD3_HUMAN |
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