Signal Transduction Antibodies 3

Anti-M6PR Antibody (CAB6296)

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SKU:
CAB6296
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-M6PR Antibody
Antibody SKU:CAB6296
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-185 of human M6PR (NP_002346.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-185 of human M6PR (NP_002346.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TEEK TCDL VGEK GKES EKEL ALVK RLKP LFNK SFES TVGQ GSDT YIYI FRVC REAG NHTS GAGL VQIN KSNG KETV VGRL NETH IFNG SNWI MLIY KGGD EYDN HCGK EQRR AVVM ISCN RHTL ADNF NPVS EERG KVQD CFYL FEMD SSLA CSPE ISH
Gene ID:4074
Uniprot:P20645
Cellular Location:Lysosome membrane, Single-pass type I membrane protein
Calculated MW:30kDa
Observed MW:31kDa
Synonyms:M6PR, CD-M6PR, CD-MPR, MPR 46, MPR-46, MPR46, SMPR
Background:This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.
UniProt Protein Function:M6PR: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: endosome; integral to plasma membrane; membrane; perinuclear region of cytoplasm; trans-Golgi network; trans-Golgi network membrane; transport vesicle

Molecular Function:transmembrane receptor activity

Biological Process: endosome to lysosome transport; receptor-mediated endocytosis

NCBI Summary:This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]
UniProt Code:P20645
NCBI GenInfo Identifier:127293
NCBI Gene ID:4074
NCBI Accession:P20645.1
UniProt Secondary Accession:P20645,A8K528, D3DUV5,
UniProt Related Accession:P20645
Molecular Weight:30,993 Da
NCBI Full Name:Cation-dependent mannose-6-phosphate receptor
NCBI Synonym Full Names:mannose-6-phosphate receptor, cation dependent
NCBI Official Symbol:M6PR  
NCBI Official Synonym Symbols:SMPR; MPR46; CD-MPR; MPR 46; MPR-46; CD-M6PR  
NCBI Protein Information:cation-dependent mannose-6-phosphate receptor
UniProt Protein Name:Cation-dependent mannose-6-phosphate receptor
UniProt Synonym Protein Names:46 kDa mannose 6-phosphate receptor; MPR 46
Protein Family:Cation-dependent mannose-6-phosphate receptor
UniProt Gene Name:M6PR  
UniProt Entry Name:MPRD_HUMAN
Anti-M6PR Antibody (CAB6296)Western blot analysis of extracts of mouse kidney, using M6PR antibody (CAB6296) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 40s.
Anti-M6PR Antibody (CAB6296)Immunohistochemistry of paraffin-embedded human liver damage using M6PR antibody (CAB6296) at dilution of 1:100 (40x lens).
Anti-M6PR Antibody (CAB6296)Immunohistochemistry of paraffin-embedded human stomach using M6PR antibody (CAB6296) at dilution of 1:100 (40x lens).
Anti-M6PR Antibody (CAB6296)Immunohistochemistry of paraffin-embedded mouse heart using M6PR antibody (CAB6296) at dilution of 1:100 (40x lens).
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