Cell Cycle Antibodies 1

Anti-LZTS2 Antibody (CAB14598)

(No reviews yet) Write a Review
SKU:
CAB14598
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-LZTS2 Antibody
Antibody SKU:CAB14598
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 470-669 of human LZTS2 (NP_115805.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:DU145, HT-29, HeLa, U-87MG, MCF7, Mouse brain, Rat kidney, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 470-669 of human LZTS2 (NP_115805.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ELVA LRVA LREA RATL RVSE GRAR GLQE AARA RELE LEAC SQEL QRHR QEAE QLRE KAGQ LDAE AAGL REPP VPPA TADP FLLA ESDE AKVQ RAAA GVGG SLRA QVER LRVE LQRE RRRG EEQR DSFE GERL AWQA EKEQ VIRY QKQL QHNY IQMY RRNR QLEQ ELQQ LSLE LEAR ELAD LGLA EQAP CICL EEIT ATEI
Gene ID:84445
Uniprot:Q9BRK4
Cellular Location:Cytoplasm, centrosome, cytoskeleton, microtubule organizing center
Calculated MW:72kDa
Observed MW:73kDa
Synonyms:LZTS2, LAPSER1
Background:The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants.
UniProt Protein Function:LZTS2: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family.
UniProt Protein Details:

Protein type:Nuclear export

Chromosomal Location of Human Ortholog: 10q24

Molecular Function:protein binding

NCBI Summary:The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Code:Q9BRK4
NCBI GenInfo Identifier:46396501
NCBI Gene ID:84445
NCBI Accession:Q9BRK4.2
UniProt Secondary Accession:Q9BRK4,Q8N3I0, Q96J79, Q96JL2, B1AL14, D3DR72,
UniProt Related Accession:Q9BRK4
Molecular Weight:72,759 Da
NCBI Full Name:Leucine zipper putative tumor suppressor 2
NCBI Synonym Full Names:leucine zipper tumor suppressor 2
NCBI Official Symbol:LZTS2  
NCBI Official Synonym Symbols:LAPSER1  
NCBI Protein Information:leucine zipper putative tumor suppressor 2
UniProt Protein Name:Leucine zipper putative tumor suppressor 2
UniProt Synonym Protein Names:Protein LAPSER1
Protein Family:Leucine zipper putative tumor suppressor
UniProt Gene Name:LZTS2  
UniProt Entry Name:LZTS2_HUMAN
Anti-LZTS2 Antibody (CAB14598)Western blot analysis of extracts of various cell lines, using LZTS2 antibody (CAB14598) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
View AllClose

0 Reviews

View AllClose

Related Products