Antibody Name:	Anti-LZTS1 Antibody
Antibody SKU:	CAB16496
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 337-596 of human LZTS1 (NP_066300.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 337-596 of human LZTS1 (NP_066300.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	QLQQ EKRQ LRQE LESL MKEQ DLLE TKLR SYER EKTS FGPA LEET QWEV CQKS GEIS LLKQ QLKE SQTE VNAK ASEI LGLK AQLK DTRG KLEG LELR TQDL EGAL RTKG LELE VCEN ELQR KKNE AELL REKV NLLE QELQ ELRA QAAL ARDM GPPT FPED VPAL QREL ERLR AELR EERQ GHDQ MSSG FQHE RLVW KEEK EKVI QYQK QLQQ SYVA MYQR NQRL EKAL QQLA RGDS AGEP LEVD LEGA DIPY EDII ATEI
Gene ID:	11178
Uniprot:	Q9Y250
Cellular Location:	Cell junction, Cell membrane, Cell projection, Cytoplasm, dendritic spine, postsynaptic cell membrane, postsynaptic density, synapse
Calculated MW:	8kDa/22kDa/55kDa/59kDa/62kDa/63kDa/66kDa
Observed MW:	Refer to figures

Synonyms:

LZTS1, F37, FEZ1

Background:

This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer.

UniProt Protein Function:	LZTS1: Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. Defects in LZTS1 may be a cause of esophageal cancer (ESCR). A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. Belongs to the LZTS family. 7 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Tumor suppressor; Transcription factor Chromosomal Location of Human Ortholog: 8p22 Molecular Function:protein binding; transcription factor activity Biological Process: negative regulation of macroautophagy Disease: Esophageal Cancer
NCBI Summary:	This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]
UniProt Code:	Q9Y250
NCBI GenInfo Identifier:	46396556
NCBI Gene ID:	11178
NCBI Accession:	Q9Y250.3
UniProt Secondary Accession:	Q9Y250,Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2 D3DSQ6,
UniProt Related Accession:	Q9Y250
Molecular Weight:	8,571 Da
NCBI Full Name:	Leucine zipper putative tumor suppressor 1
NCBI Synonym Full Names:	leucine zipper tumor suppressor 1
NCBI Official Symbol:	LZTS1
NCBI Official Synonym Symbols:	F37; FEZ1
NCBI Protein Information:	leucine zipper putative tumor suppressor 1
UniProt Protein Name:	Leucine zipper putative tumor suppressor 1
UniProt Synonym Protein Names:	F37/esophageal cancer-related gene-coding leucine-zipper motif; Fez1
Protein Family:	Leucine zipper putative tumor suppressor
UniProt Gene Name:	LZTS1
UniProt Entry Name:	LZTS1_HUMAN