Signal Transduction Antibodies 3
Anti-LZTR1 Antibody (CAB7350)
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- SKU:
- CAB7350
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-LZTR1 Antibody |
| Antibody SKU: | CAB7350 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-545 of human LZTR1 (NP_006758.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | BT-474, SKOV3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-545 of human LZTR1 (NP_006758.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GGAA DNTL PNEL HCYD VDFQ TWEV VQPS SDSE VGGA EVPE RACA SEEV PTLT YEER VGFK KSRD VFGL DFGT TSAK QPTQ PASE LPSG RLFH AAAV ISDA MYIF GGTV DNNI RSGE MYRF QFSC YPKC TLHE DYGR LWES RQFC DVEF VLGE KEEC VQGH VAIV TARS RWLR RKIT QARE RLAQ KLEQ EAAP VPRE APGV AAGG ARPP LLHV AIRE AEAR PFEV LMQF LYTD KIKY PRKG HVED VL |
| Gene ID: | 8216 |
| Uniprot: | Q8N653 |
| Cellular Location: | |
| Calculated MW: | 94kDa |
| Observed MW: | 110kDa |
| Synonyms: | LZTR1, BTBD29, LZTR-1, NS10, SWNTS2 |
| Background: | This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. |
| UniProt Protein Function: | LZTR1: Probable transcriptional regulator that may play a crucial role in embryogenesis. |
| UniProt Protein Details: | Protein type:Transcription factor; EC 3.4.22.- Chromosomal Location of Human Ortholog: 22q11.21|22q11.1-q11.2 Molecular Function:transcription factor activity Biological Process: anatomical structure morphogenesis; regulation of transcription, DNA-dependent Disease: Schwannomatosis 2 |
| NCBI Summary: | This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8N653 |
| NCBI GenInfo Identifier: | 29839558 |
| NCBI Gene ID: | 8216 |
| NCBI Accession: | Q8N653.2 |
| UniProt Secondary Accession: | Q8N653,Q14776, Q20WK0, |
| UniProt Related Accession: | Q8N653 |
| Molecular Weight: | 840 |
| NCBI Full Name: | Leucine-zipper-like transcriptional regulator 1 |
| NCBI Synonym Full Names: | leucine-zipper-like transcription regulator 1 |
| NCBI Official Symbol: | LZTR1 |
| NCBI Official Synonym Symbols: | BTBD29; LZTR-1; SWNTS2 |
| NCBI Protein Information: | leucine-zipper-like transcriptional regulator 1; leucine-zipper-like regulator-1 |
| UniProt Protein Name: | Leucine-zipper-like transcriptional regulator 1 |
| Protein Family: | Leucine-zipper-like transcriptional regulator |
| UniProt Gene Name: | LZTR1 |
| UniProt Entry Name: | LZTR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LZTR1 antibody (CAB7350) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human kidney using LZTR1 antibody (CAB7350) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of Raw264.7 cells using LZTR1 antibody (CAB7350) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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