Signal Transduction Antibodies 3

Anti-LYVE1 Antibody (CAB6452)

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SKU:
CAB6452
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-LYVE1 Antibody
Antibody SKU:CAB6452
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-238 of human LYVE1 (NP_006682.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse aorta, Mouse heart, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-238 of human LYVE1 (NP_006682.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LVQG SLRA EELS IQVS CRIM GITL VSKK ANQQ LNFT EAKE ACRL LGLS LAGK DQVE TALK ASFE TCSY GWVG DGFV VISR ISPN PKCG KNGV GVLI WKVP VSRQ FAAY CYNS SDTW TNSC IPEI ITTK DPIF NTQT ATQT TEFI VSDS TYSV ASPY STIP APTT TPPA PAST SIPR RKKL ICVT EVFM ETST MSTE TEPF VENK AAFK NEAA GFGG VPT
Gene ID:10894
Uniprot:Q9Y5Y7
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:35kDa
Observed MW:33kDa
Synonyms:LYVE1, CRSBP-1, HAR, LYVE-1, XLKD1
Background:This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis.
UniProt Protein Function:XLKD1: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
UniProt Protein Details:

Protein type:Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function:transmembrane receptor activity; hyaluronic acid binding; receptor activity

Biological Process: anatomical structure morphogenesis; glycosaminoglycan metabolic process; transport; cell-matrix adhesion; carbohydrate metabolic process; response to wounding; pathogenesis; signal transduction; cell motility; hyaluronan metabolic process; hyaluronan catabolic process

NCBI Summary:This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y5Y7
NCBI GenInfo Identifier:115502898
NCBI Gene ID:10894
NCBI Accession:Q9Y5Y7.2
UniProt Secondary Accession:Q9Y5Y7,Q8TC18, Q9UNF4,
UniProt Related Accession:Q9Y5Y7
Molecular Weight:35,213 Da
NCBI Full Name:Lymphatic vessel endothelial hyaluronic acid receptor 1
NCBI Synonym Full Names:lymphatic vessel endothelial hyaluronan receptor 1
NCBI Official Symbol:LYVE1  
NCBI Official Synonym Symbols:HAR; XLKD1; LYVE-1; CRSBP-1  
NCBI Protein Information:lymphatic vessel endothelial hyaluronic acid receptor 1; cell surface retention sequence binding protein-1; cell surface retention sequence-binding protein 1; extracellular link domain containing 1; extracellular link domain-containing 1; extracellular link domain-containing protein 1
UniProt Protein Name:Lymphatic vessel endothelial hyaluronic acid receptor 1
UniProt Synonym Protein Names:Cell surface retention sequence-binding protein 1; CRSBP-1; Extracellular link domain-containing protein 1; Hyaluronic acid receptor
Protein Family:Lymphatic vessel endothelial hyaluronic acid receptor
UniProt Gene Name:LYVE1  
UniProt Entry Name:LYVE1_HUMAN
Anti-LYVE1 Antibody (CAB6452)Western blot analysis of extracts of various cell lines, using LYVE1 antibody (CAB6452) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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