Cell Biology Antibodies 14
Anti-LYST Antibody (CAB18139)
- SKU:
- CAB18139
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-LYST Antibody |
| Antibody SKU: | CAB18139 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human LYST. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human LYST. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1130 |
| Uniprot: | Q99698 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | CHS, CHS1, LYST |
| Background: |
| UniProt Protein Function: | LYST: May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules. Defects in LYST are the cause of Chediak-Higashi syndrome (CHS). CHS is a rare autosomal recessive disorder characterized by hypopigmentation, severe immunologic deficiency, a bleeding tendency, neurologic abnormalities, abnormal intracellular transport to and from the lysosome, and giant inclusion bodies in a variety of cell types. Most patients die at an early age unless they receive an allogeneic hematopoietic stem cell transplant (SCT). 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1q42.1-q42.2 Cellular Component: microtubule cytoskeleton; extrinsic to membrane; endomembrane system; cytosol Molecular Function:protein binding; phospholipid binding Biological Process: response to drug; secretion of lysosomal enzymes; natural killer cell mediated cytotoxicity; T cell mediated immunity; leukocyte chemotaxis; neutrophil mediated immunity; mast cell secretory granule organization and biogenesis; defense response to protozoan; endosome to lysosome transport via multivesicular body sorting pathway; positive regulation of natural killer cell activation; microtubule-based process; pigmentation; melanosome organization and biogenesis; lysosome organization and biogenesis; phospholipid metabolic process; defense response to bacterium; blood coagulation; defense response to virus; phospholipid homeostasis Disease: Chediak-higashi Syndrome |
| NCBI Summary: | This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants, though the full-length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2013] |
| UniProt Code: | Q99698 |
| NCBI GenInfo Identifier: | 54292123 |
| NCBI Gene ID: | 1130 |
| NCBI Accession: | NP_000072.2 |
| UniProt Secondary Accession: | Q99698,O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133 |
| UniProt Related Accession: | Q99698 |
| Molecular Weight: | 429,139 Da |
| NCBI Full Name: | lysosomal-trafficking regulator |
| NCBI Synonym Full Names: | lysosomal trafficking regulator |
| NCBI Official Symbol: | LYST |
| NCBI Official Synonym Symbols: | CHS; CHS1 |
| NCBI Protein Information: | lysosomal-trafficking regulator; beige homolog; Chediak-Higashi syndrome 1 |
| UniProt Protein Name: | Lysosomal-trafficking regulator |
| UniProt Synonym Protein Names: | Beige homolog |
| Protein Family: | Lysosomal-trafficking regulator |
| UniProt Gene Name: | LYST |
| UniProt Entry Name: | LYST_HUMAN |
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