Signal Transduction Antibodies 2

Anti-LYRM1 Antibody (CAB15483)

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SKU:
CAB15483
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-LYRM1 Antibody
Antibody SKU:CAB15483
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-122 of human LYRM1 (NP_065157.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse testis, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-122 of human LYRM1 (NP_065157.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MTTA TRQE VLGL YRSI FRLA RKWQ ATSG QMED TIKE KQYI LNEA RTLF RKNK NLTD TDLI KQCI DECT ARIE IGLH YKIP YPRP IHLP PMGL TPLR GRGL RSQE KLRK LSKP VYLR SHDE VS
Gene ID:57149
Uniprot:O43325
Cellular Location:Nucleus
Calculated MW:14kDa
Observed MW:14kDa
Synonyms:LYRM1, A211C6.1
Background:The protein encoded by this gene belongs to the mitochondrial leucine/tyrosine/arginine motif family of proteins. Proteins of this family are short polypeptides that contain a leucine/tyrosine/arginine motif near the N-terminus. This gene is widely expressed with high levels in omental adipose tissue of obese individuals. In adipose tissue, the protein is localized to the nucleus where it promotes preadipocyte proliferation and lowers the rate of apoptosis to regulate adipose tissue homeostasis. Overexpression of this gene in adipocytes causes abnormal mitochondrial morphology and mitochondrial dysfunction. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:LYRM1: May promote cell proliferation and inhibition of apoptosis of preadipocytes. When overexpressed, may be involved in obesity- associated insulin resistance, possibly by causing mitochondrial dysfunction in adipocytes. Belongs to the complex I LYR family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: nucleoplasm; intercellular bridge; mitochondrion

NCBI Summary:The protein encoded by this gene belongs to the mitochondrial leucine/tyrosine/arginine motif family of proteins. Proteins of this family are short polypeptides that contain a leucine/tyrosine/arginine motif near the N-terminus. This gene is widely expressed with high levels in omental adipose tissue of obese individuals. In adipose tissue, the protein is localized to the nucleus where it promotes preadipocyte proliferation and lowers the rate of apoptosis to regulate adipose tissue homeostasis. Overexpression of this gene in adipocytes causes abnormal mitochondrial morphology and mitochondrial dysfunction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
UniProt Code:O43325
NCBI GenInfo Identifier:119587248
NCBI Gene ID:57149
NCBI Accession:EAW66844
UniProt Related Accession:O43325
Molecular Weight:14 kDa
NCBI Full Name:hypothetical protein A-211C6.1, isoform CRA_b
NCBI Synonym Full Names:LYR motif containing 1
NCBI Official Symbol:LYRM1  
NCBI Official Synonym Symbols:A211C6.1  
NCBI Protein Information:LYR motif-containing protein 1
UniProt Protein Name:LYR motif-containing protein 1
Protein Family:LYR motif containing protein
UniProt Gene Name:LYRM1  
UniProt Entry Name:LYRM1_HUMAN
Anti-LYRM1 Antibody (CAB15483)Western blot analysis of extracts of various cell lines, using LYRM1 antibody (CAB15483) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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