Signal Transduction Antibodies 2
Anti-LYRM1 Antibody (CAB15483)
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- SKU:
- CAB15483
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-LYRM1 Antibody |
| Antibody SKU: | CAB15483 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-122 of human LYRM1 (NP_065157.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse testis, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-122 of human LYRM1 (NP_065157.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTTA TRQE VLGL YRSI FRLA RKWQ ATSG QMED TIKE KQYI LNEA RTLF RKNK NLTD TDLI KQCI DECT ARIE IGLH YKIP YPRP IHLP PMGL TPLR GRGL RSQE KLRK LSKP VYLR SHDE VS |
| Gene ID: | 57149 |
| Uniprot: | O43325 |
| Cellular Location: | Nucleus |
| Calculated MW: | 14kDa |
| Observed MW: | 14kDa |
| Synonyms: | LYRM1, A211C6.1 |
| Background: | The protein encoded by this gene belongs to the mitochondrial leucine/tyrosine/arginine motif family of proteins. Proteins of this family are short polypeptides that contain a leucine/tyrosine/arginine motif near the N-terminus. This gene is widely expressed with high levels in omental adipose tissue of obese individuals. In adipose tissue, the protein is localized to the nucleus where it promotes preadipocyte proliferation and lowers the rate of apoptosis to regulate adipose tissue homeostasis. Overexpression of this gene in adipocytes causes abnormal mitochondrial morphology and mitochondrial dysfunction. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | LYRM1: May promote cell proliferation and inhibition of apoptosis of preadipocytes. When overexpressed, may be involved in obesity- associated insulin resistance, possibly by causing mitochondrial dysfunction in adipocytes. Belongs to the complex I LYR family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: nucleoplasm; intercellular bridge; mitochondrion |
| NCBI Summary: | The protein encoded by this gene belongs to the mitochondrial leucine/tyrosine/arginine motif family of proteins. Proteins of this family are short polypeptides that contain a leucine/tyrosine/arginine motif near the N-terminus. This gene is widely expressed with high levels in omental adipose tissue of obese individuals. In adipose tissue, the protein is localized to the nucleus where it promotes preadipocyte proliferation and lowers the rate of apoptosis to regulate adipose tissue homeostasis. Overexpression of this gene in adipocytes causes abnormal mitochondrial morphology and mitochondrial dysfunction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] |
| UniProt Code: | O43325 |
| NCBI GenInfo Identifier: | 119587248 |
| NCBI Gene ID: | 57149 |
| NCBI Accession: | EAW66844 |
| UniProt Related Accession: | O43325 |
| Molecular Weight: | 14 kDa |
| NCBI Full Name: | hypothetical protein A-211C6.1, isoform CRA_b |
| NCBI Synonym Full Names: | LYR motif containing 1 |
| NCBI Official Symbol: | LYRM1 |
| NCBI Official Synonym Symbols: | A211C6.1 |
| NCBI Protein Information: | LYR motif-containing protein 1 |
| UniProt Protein Name: | LYR motif-containing protein 1 |
| Protein Family: | LYR motif containing protein |
| UniProt Gene Name: | LYRM1 |
| UniProt Entry Name: | LYRM1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LYRM1 antibody (CAB15483) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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