Cell Biology Antibodies 9

Anti-LUM Antibody (CAB5352)

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SKU:
CAB5352
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-LUM Antibody
Antibody SKU:CAB5352
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 19-338 of human LUM (NP_002336.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, Mouse skeletal muscle, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 19-338 of human LUM (NP_002336.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QYYD YDFP LSIY GQSS PNCA PECN CPES YPSA MYCD ELKL KSVP MVPP GIKY LYLR NNQI DHID EKAF ENVT DLQW LILD HNLL ENSK IKGR VFSK LKQL KKLH INHN NLTE SVGP LPKS LEDL QLTH NKIT KLGS FEGL VNLT FIHL QHNR LKED AVSA AFKG LKSL EYLD LSFN QIAR LPSG LPVS LLTL YLDN NKIS NIPD EYFK RFNA LQYL RLSH NELA DSGI PGNS FNVS SLVE LDLS YNKL KNIP TVNE NLEN YYLE VNQL EKFD IKSF CKIL GPLS YSKI KHLR LDGN RISE TSLP PDMY ECLR VANE VTLN
Gene ID:4060
Uniprot:P51884
Cellular Location:Secreted, extracellular matrix, extracellular space
Calculated MW:38kDa
Observed MW:48kDa
Synonyms:LUM, LDC, SLRR2D, lumican
Background:This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.
UniProt Protein Function:LUM: a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q21.33

Cellular Component: extracellular matrix; extracellular region; extracellular space; fibrillar collagen; Golgi lumen; lysosomal lumen; proteinaceous extracellular matrix

Molecular Function:collagen binding; protein binding

Biological Process: axonogenesis; extracellular matrix organization and biogenesis; keratan sulfate biosynthetic process; keratan sulfate catabolic process

NCBI Summary:This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]
UniProt Code:P51884
NCBI GenInfo Identifier:20141464
NCBI Gene ID:4060
NCBI Accession:P51884.2
UniProt Secondary Accession:P51884,Q96QM7, B2R6R5,
UniProt Related Accession:P51884
Molecular Weight:38,429 Da
NCBI Full Name:Lumican
NCBI Synonym Full Names:lumican
NCBI Official Symbol:LUM  
NCBI Official Synonym Symbols:LDC; SLRR2D  
NCBI Protein Information:lumican
UniProt Protein Name:Lumican
UniProt Synonym Protein Names:Keratan sulfate proteoglycan lumican; KSPG lumican
Protein Family:Lumican
UniProt Gene Name:LUM  
UniProt Entry Name:LUM_HUMAN
Anti-LUM Antibody (CAB5352)Western blot analysis of extracts of various cell lines, using LUM antibody (CAB5352) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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