Cell Biology Antibodies 3

Anti-LUC7L2 Antibody (CAB13096)

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SKU:
CAB13096
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-LUC7L2 Antibody
Antibody SKU:CAB13096
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 313-392 of human LUC7L2 (NP_057103.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:K-562, 293T, HeLa, Mouse kidney, Mouse heart, Mouse thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 313-392 of human LUC7L2 (NP_057103.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SRSH QRSR HSSR DRSR ERSK RRSS KERF RDQD LASC DRDR SSRD RSPR DRDR KDKK RSYE SANG RSED RRSS EERE AGEI
Gene ID:51631
Uniprot:Q9Y383
Cellular Location:Nucleus, Nucleus speckle, nucleoplasm
Calculated MW:46kDa
Observed MW:46kDa
Synonyms:LUC7L2, CGI-59, CGI-74, LUC7B2, LUC7 like 2
Background:This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniProt Protein Function:LUC7L2: a Luc7 family protein that may bind RNA via its Arg/Ser-rich domain. Contains 1 C2H2-type zinc finger. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:RNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: nuclear speck; snRNP U1

Molecular Function:enzyme binding; mRNA binding; protein binding

Biological Process: mRNA splice site selection

NCBI Summary:This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
UniProt Code:Q9Y383
NCBI GenInfo Identifier:47116960
NCBI Gene ID:51631
NCBI Accession:Q9Y383.2
UniProt Secondary Accession:Q9Y383,Q8IUP9, Q9NVL3, Q9NVN7, Q9UQN1, B7Z500,
UniProt Related Accession:Q9Y383
Molecular Weight:
NCBI Full Name:Putative RNA-binding protein Luc7-like 2
NCBI Synonym Full Names:LUC7-like 2 pre-mRNA splicing factor
NCBI Official Symbol:LUC7L2  
NCBI Official Synonym Symbols:CGI-59; CGI-74; LUC7B2  
NCBI Protein Information:putative RNA-binding protein Luc7-like 2
UniProt Protein Name:Putative RNA-binding protein Luc7-like 2
Protein Family:Putative RNA-binding protein
UniProt Gene Name:LUC7L2  
UniProt Entry Name:LC7L2_HUMAN
Anti-LUC7L2 Antibody (CAB13096)Western blot analysis of extracts of various cell lines, using LUC7L2 antibody (CAB13096) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
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