Metabolism Antibodies 1

Anti-LTC4S Antibody (CAB15071)

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SKU:
CAB15071

Description

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Antibody Name:Anti-LTC4S Antibody
Antibody SKU:CAB15071
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human LTC4S (NP_665874.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:A-549
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human LTC4S (NP_665874.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YRAQ VNCS EYFP LFLA TLWV AGIF FHEG AAAL CGLV YLFA RLRY FQGY ARSA QLRL APLY ASAR ALWL LVAL AALG LLAH FLPA ALRA ALLG RLRT LLPW A
Gene ID:4056
Uniprot:Q16873
Cellular Location:Endoplasmic reticulum membrane, Multi-pass membrane protein, Nucleus outer membrane
Calculated MW:16kDa
Observed MW:17kDa
Synonyms:LTC4S
Background:The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum.
UniProt Protein Function:LTC4S: Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency). LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly. Belongs to the MAPEG family.
UniProt Protein Details:

Protein type:Lyase; Nuclear envelope; Membrane protein, integral; EC 4.4.1.20; Membrane protein, multi-pass; Lipid Metabolism - arachidonic acid; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: endoplasmic reticulum; intracellular membrane-bound organelle; nuclear envelope

Molecular Function:glutathione peroxidase activity; glutathione transferase activity; leukotriene-C4 synthase activity; lipid binding; protein binding

Biological Process: leukotriene biosynthetic process; leukotriene metabolic process; lipoxygenase pathway

Disease: Leukotriene C4 Synthase Deficiency

NCBI Summary:The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]
UniProt Code:Q16873
NCBI GenInfo Identifier:2833283
NCBI Gene ID:4056
NCBI Accession:Q16873.1
UniProt Secondary Accession:Q16873,Q8N6P0, Q9UC73, Q9UD18,
UniProt Related Accession:Q16873
Molecular Weight:16,567 Da
NCBI Full Name:Leukotriene C4 synthase
NCBI Synonym Full Names:leukotriene C4 synthase
NCBI Official Symbol:LTC4S  
NCBI Protein Information:leukotriene C4 synthase
UniProt Protein Name:Leukotriene C4 synthase
UniProt Synonym Protein Names:Leukotriene-C(4) synthase
Protein Family:Leukotriene C4 synthase
UniProt Gene Name:LTC4S  
UniProt Entry Name:LTC4S_HUMAN
Anti-LTC4S Antibody (CAB15071)Western blot analysis of extracts of A-549 cells, using LTC4S antibody (CAB15071) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90.
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Additional Information

Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
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