Name: Anti-LTBP1 Antibody (CAB15287)
Brand: Cell Biology Antibodies 5
SKU: CAB15287
Availability: OutOfStock

Antibody Name:	Anti-LTBP1 Antibody
Antibody SKU:	CAB15287
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1290-1540 of human LTBP1 (NP_996826.2).

Application:	WB
Recommended Dilution:	WB 1:200 - 1:2000
Reactivity:	Human
Positive Samples:	LO2

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1290-1540 of human LTBP1 (NP_996826.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	CELL SGVC GEAF CENV EGSF LCVC ADEN QEYS PMTG QCRS RTST DLDV DVDQ PKEE KKEC YYNL NDAS LCDN VLAP NVTK QECC CTSG AGWG DNCE IFPC PVLG TAEF TEMC PKGK GFVP AGES SSEA GGEN YKDA DECL LFGQ EICK NGFC LNTR PGYE CYCK QGTY YDPV KLQC FDMD ECQD PSSC IDGQ CVNT EGSY NCFC THPM VLDA SEKR CIRP AESN EQIE ETDV YQDL CWEH LSDE YVCS RPL
Gene ID:	4052
Uniprot:	Q14766
Cellular Location:	Secreted
Calculated MW:	147kDa/152kDa/153kDa/186kDa
Observed MW:	150kDa

Synonyms:

LTBP1

Background:

The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.

UniProt Protein Function:	LTBP1: May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM). Belongs to the LTBP family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Chaperone; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2p22-p21 Cellular Component: extracellular matrix; extracellular region; microfibril; protein complex Molecular Function:microfibril binding; protein binding; transforming growth factor beta binding
NCBI Summary:	The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:	Q14766
NCBI GenInfo Identifier:	290457687
NCBI Gene ID:	4052
NCBI Accession:	Q14766.4
UniProt Secondary Accession:	Q14766,P22064, Q53SD8, Q53SF3, Q53SG1, Q59HF7, Q8TD95 A1L3V1,
UniProt Related Accession:	Q14766
Molecular Weight:	153,006 Da
NCBI Full Name:	Latent-transforming growth factor beta-binding protein 1
NCBI Synonym Full Names:	latent transforming growth factor beta binding protein 1
NCBI Official Symbol:	LTBP1
NCBI Protein Information:	latent-transforming growth factor beta-binding protein 1
UniProt Protein Name:	Latent-transforming growth factor beta-binding protein 1
UniProt Synonym Protein Names:	Transforming growth factor beta-1-binding protein 1; TGF-beta1-BP-1
Protein Family:	Latent-transforming growth factor beta-binding protein
UniProt Gene Name:	LTBP1
UniProt Entry Name:	LTBP1_HUMAN

Western blot analysis of extracts of LO2 cells, using LTBP1 antibody (CAB15287) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

ELISA Kits

Human LTBP1 (Latent-transforming growth factor beta-binding protein 1) ELISA Kit (HUFI03563)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)