Metabolism Antibodies 2
Anti-LSS Antibody (CAB6930)
- SKU:
- CAB6930
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-LSS Antibody |
| Antibody SKU: | CAB6930 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human LSS (NP_002331.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | BT-474, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human LSS (NP_002331.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTEG TCLR RRGG PYKT EPAT DLGR WRLN CERG RQTW TYLQ DERA GREQ TGLE AYAL GLDT KNYF KDLP KAHT AFEG ALNG MTFY VGLQ AEDG HWTG DYGG PLFL LPGL LITC HVAR IPLP AGYR EEIV RYLR SVQL PDGG WGLH IEDK STVF GTAL NYVS LRIL GVGP DDPD LVRA RNIL HKKG GAVA IPSW GKFW LAVL NVYS WEGL NTLF PEMW LFPD WAPA HPST LWCH CRQV YLPM SYCY AVRL SAAE DPLV QSLR QELY VEDF ASID WLAQ RNNV APDE LYTP HSWL LRVV YALL |
| Gene ID: | 4047 |
| Uniprot: | P48449 |
| Cellular Location: | Endoplasmic reticulum membrane, Peripheral membrane protein |
| Calculated MW: | 74kDa/82kDa/83kDa |
| Observed MW: | 75kDa |
| Synonyms: | LSS, CTRCT44, OSC |
| Background: | The protein encoded by this gene catalyzes the conversion of (S)-2, 3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | LSS: Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Belongs to the terpene cyclase/mutase family. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - steroid biosynthesis; EC 5.4.99.7; Isomerase Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: endoplasmic reticulum membrane; membrane; lipid particle Molecular Function:lanosterol synthase activity Biological Process: steroid metabolic process; cholesterol biosynthetic process Disease: Cataract 44 |
| NCBI Summary: | The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009] |
| UniProt Code: | P48449 |
| NCBI GenInfo Identifier: | 1352387 |
| NCBI Gene ID: | 4047 |
| NCBI Accession: | P48449.1 |
| UniProt Secondary Accession: | P48449,Q8IYL6, Q9UEZ1, B4DJZ9, D3DSN0, E9PEI9, G5E9Q9 |
| UniProt Related Accession: | P48449 |
| Molecular Weight: | 82,199 Da |
| NCBI Full Name: | Lanosterol synthase |
| NCBI Synonym Full Names: | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) |
| NCBI Official Symbol: | LSS |
| NCBI Official Synonym Symbols: | OSC |
| NCBI Protein Information: | lanosterol synthase; hOSC; oxidosqualene--lanosterol cyclase; 2,3-epoxysqualene-lanosterol cyclase; 2,3-epoxysqualene--lanosterol cyclase |
| UniProt Protein Name: | Lanosterol synthase |
| UniProt Synonym Protein Names: | 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC; hOSC |
| Protein Family: | Lysostaphin |
| UniProt Gene Name: | LSS |
| UniProt Entry Name: | ERG7_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LSS antibody (CAB6930) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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