Cell Biology Antibodies 4
Anti-LSP1 Antibody (CAB13624)
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- SKU:
- CAB13624
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-LSP1 Antibody |
| Antibody SKU: | CAB13624 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human LSP1 (NP_002330.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Jurkat, NCI-H460, BT-474, HT-29, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human LSP1 (NP_002330.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAEA SSDP GAEE REEL LGPT AQWS VEDE EEAV HEQC QHER DRQL QAQD EEGG GHVP ERPK QEML LSLK PSEA PELD EDEG FGDW SQRP EQRQ QHEG AQGA LDSG EPPQ CRSP EGEQ EDRP GLHA YEKE DSDE VHLE ELSL SKEG PGPE DTVQ DNLG AAGA EEEQ EEHQ KCQQ PRTP SPLV LEGT IEQS SPPL SPTT KLID RTES LNRS IEKS NSVK KSQP DLPI SKID QWLE QYTQ AIET AGRT PKLA RQAS IELP SMAV ASTK SRWE TGEV QAQS AAKT PSCK DIVA GDMS KKSL WEQK GGSK TSST IKST PSGK RYKF VATG HGKY EKVL VEGG PAP |
| Gene ID: | 4046 |
| Uniprot: | P33241 |
| Cellular Location: | Cell membrane, Cytoplasmic side, Peripheral membrane protein |
| Calculated MW: | 30kDa/37kDa/50kDa |
| Observed MW: | 57kDa |
| Synonyms: | LSP1, WP34, pp52 |
| Background: | This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | LSP1: May play a role in mediating neutrophil activation and chemotaxis. Binds actin. Activated T-lymphocytes. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: membrane; plasma membrane; actin cytoskeleton Molecular Function:signal transducer activity; actin binding Biological Process: cellular defense response; cell motility; signal transduction; chemotaxis |
| NCBI Summary: | This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P33241 |
| NCBI GenInfo Identifier: | 462553 |
| NCBI Gene ID: | 4046 |
| NCBI Accession: | P33241.1 |
| UniProt Secondary Accession: | P33241,Q16096, Q53H48, Q6FHM3, Q9BUY8, B3KPP1, B3KRR6 E9PBV6, E9PFP3, |
| UniProt Related Accession: | P33241 |
| Molecular Weight: | 339 |
| NCBI Full Name: | Lymphocyte-specific protein 1 |
| NCBI Synonym Full Names: | lymphocyte-specific protein 1 |
| NCBI Official Symbol: | LSP1 |
| NCBI Official Synonym Symbols: | WP34; pp52 |
| NCBI Protein Information: | lymphocyte-specific protein 1; 52 kDa phosphoprotein; 47 kDa actin binding protein; 47 kDa actin-binding protein; leukocyte-specific protein 1; lymphocyte-specific antigen WP34; leufactin (leukocyte F-actin binding protein); F-actin binding and cytoskeleton associated protein |
| UniProt Protein Name: | Lymphocyte-specific protein 1 |
| UniProt Synonym Protein Names: | 47 kDa actin-binding protein; 52 kDa phosphoprotein; pp52; Lymphocyte-specific antigen WP34 |
| Protein Family: | Lymphocyte-specific protein |
| UniProt Gene Name: | LSP1 |
| UniProt Entry Name: | LSP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LSP1 antibody (CAB13624) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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