Epigenetics & Nuclear Signaling Antibodies 2
Anti-LSM4 Antibody (CAB5891)
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- SKU:
- CAB5891
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-LSM4 Antibody |
| Antibody SKU: | CAB5891 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-139 of human LSM4 (NP_036453.1). |
| Application: | WB IHC IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 22Rv1, HepG2, MCF7, Jurkat, Mouse kidney, Mouse heart, Mouse thymus, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-139 of human LSM4 (NP_036453.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLPL SLLK TAQN HPML VELK NGET YNGH LVSC DNWM NINL REVI CTSR DGDK FWRM PECY IRGS TIKY LRIP DEII DMVK EEVV AKGR GRGG LQQQ KQQK GRGM GGAG RGVF GGRG RGGI PGTG RGQP EKKP GRQA GKQ |
| Gene ID: | 25804 |
| Uniprot: | Q9Y4Z0 |
| Cellular Location: | Nucleus |
| Calculated MW: | 15kDa |
| Observed MW: | 15kDa |
| Synonyms: | LSM4, GRP, YER112W |
| Background: | This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | LSM4: Binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family. |
| UniProt Protein Details: | Protein type:RNA-binding; Spliceosome Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: small nuclear ribonucleoprotein complex; spliceosome; cytosol Molecular Function:protein binding Biological Process: RNA splicing; gene expression; mRNA processing; mRNA catabolic process, deadenylation-dependent decay |
| NCBI Summary: | This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9Y4Z0 |
| NCBI GenInfo Identifier: | 10720082 |
| NCBI Gene ID: | 25804 |
| NCBI Accession: | Q9Y4Z0.1 |
| UniProt Related Accession: | Q9Y4Z0 |
| Molecular Weight: | Calculated MW: 15kDaObserved MW: 15kDa |
| NCBI Full Name: | U6 snRNA-associated Sm-like protein LSm4 |
| NCBI Synonym Full Names: | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
| NCBI Official Symbol: | LSM4 |
| NCBI Official Synonym Symbols: | GRP; YER112W |
| NCBI Protein Information: | U6 snRNA-associated Sm-like protein LSm4; glycine-rich protein |
| UniProt Protein Name: | U6 snRNA-associated Sm-like protein LSm4 |
| UniProt Synonym Protein Names: | Glycine-rich protein; GRP |
| Protein Family: | Sm-like protein |
| UniProt Gene Name: | LSM4 |
| UniProt Entry Name: | LSM4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LSM4 antibody (CAB5891) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded human mammary cancer using LSM4 antibody (CAB5891) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using LSM4 antibody (CAB5891) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human lung cancer using LSM4 antibody (CAB5891) at dilution of 1:100 (40x lens). |
 | Immunoprecipitation analysis of 200ug extracts of Jurkat cells using 1ug LSM4 antibody (CAB5891). Western blot was performed from the immunoprecipitate using LSM4 antibody (CAB5891) at a dilition of 1:1000. |
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