Epigenetics & Nuclear Signaling Antibodies 4
Anti-LSM2 Antibody (CAB7988)
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- SKU:
- CAB7988
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | LSM2 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB7988 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-95 of human LSM2 (NP_067000.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | SW620, SKOV3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-95 of human LSM2 (NP_067000.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLFY SFFK SLVG KDVV VELK NDLS ICGT LHSV DQYL NIKL TDIS VTDP EKYP HMLS VKNC FIRG SVVR YVQL PADE VDTQ LLQD AARK EALQ QKQ |
| Gene ID: | 57819 |
| Uniprot: | Q9Y333 |
| Cellular Location: | Nucleus |
| Calculated MW: | 10kDa |
| Observed MW: | 13kDa |
| Synonyms: | LSM2, C6orf28, G7B, YBL026W, snRNP |
| Background: | This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. |
| UniProt Protein Function: | LSM2: Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing. Identified in the spliceosome C complex. LSm subunits form a heteromer with a doughnut shape. Belongs to the snRNP Sm proteins family. |
| UniProt Protein Details: | Protein type:RNA splicing; Spliceosome; RNA-binding Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: cytosol; nucleoplasm; U4/U6 x U5 tri-snRNP complex Molecular Function:protein binding; Ral GTPase binding; RNA binding Biological Process: nuclear mRNA splicing, via spliceosome |
| NCBI Summary: | This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9Y333 |
| NCBI GenInfo Identifier: | 10720079 |
| NCBI Gene ID: | 57819 |
| NCBI Accession: | Q9Y333.1 |
| UniProt Secondary Accession: | Q9Y333,Q6FGG1, |
| UniProt Related Accession: | Q9Y333 |
| Molecular Weight: | 10,835 Da |
| NCBI Full Name: | U6 snRNA-associated Sm-like protein LSm2 |
| NCBI Synonym Full Names: | LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated |
| NCBI Official Symbol: | LSM2 |
| NCBI Official Synonym Symbols: | G7B; snRNP; C6orf28; YBL026W |
| NCBI Protein Information: | U6 snRNA-associated Sm-like protein LSm2 |
| UniProt Protein Name: | U6 snRNA-associated Sm-like protein LSm2 |
| UniProt Synonym Protein Names: | Protein G7b; Small nuclear ribonuclear protein D homolog; snRNP core Sm-like protein Sm-x5 |
| Protein Family: | Sm-like protein |
| UniProt Gene Name: | LSM2 |
| UniProt Entry Name: | LSM2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using LSM2 antibody (CAB7988) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using LSM2 antibody (CAB7988) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using LSM2 antibody (CAB7988) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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